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MeSH Review

Substance-Related Disorders

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Disease relevance of Substance-Related Disorders


Psychiatry related information on Substance-Related Disorders


High impact information on Substance-Related Disorders

  • We conclude that the Oprd1-encoded receptor, which has been proposed to be a promising target for the clinical management of pain, should also be considered in the treatment of drug addiction and other mood-related disorders [11].
  • Substance abuse, particularly cocaine use, is a significant correlate of violent injuries [12].
  • Corticotropin-releasing hormone (CRH) is a potent mediator of endocrine, autonomic, behavioural and immune responses to stress, and has been implicated in the stress-like and other aversive consequences of drug abuse, such as withdrawal from alcohol [13].
  • Although neurons in this area respond to rewards on a subsecond timescale, neurochemical studies have only addressed the role of dopamine in drug addiction by examining changes in the tonic (minute-to-minute) levels of extracellular dopamine [14].
  • We conclude that substance P has an important and specific role in mediating the motivational aspects of opiates and may represent a new pharmacological route for the control of drug abuse [15].

Chemical compound and disease context of Substance-Related Disorders


Biological context of Substance-Related Disorders


Anatomical context of Substance-Related Disorders


Gene context of Substance-Related Disorders

  • Our findings provide a framework to define the protein interactions and neural circuit by which this gene's product (multiple PDZ domain protein) affects drug dependence, withdrawal and relapse [31].
  • Our results reveal an unexpected complexity of ERK-dependent signaling in the brain and a critical regulatory role for ERK1 in the long-term adaptive changes underlying striatum-dependent behavioral plasticity and drug addiction [32].
  • The possibility of decreasing the behavioral and dopaminergic effects of opioids by an acute administration of GR antagonists may open new therapeutic strategies for treatment of drug addiction [33].
  • Here we show that the mouse homologues of the Drosophila Per gene, mPer1 and mPer2, modulate cocaine sensitization and reward, two phenomena extensively studied in humans and animals because of their importance for drug abuse [34].
  • These findings indicate that the natural 385A SNP in the human FAAH gene produces a mutant enzyme with reduced cellular stability, thus fortifying a potential link between functional abnormalities in the endocannabinoid system and drug abuse and dependence [35].

Analytical, diagnostic and therapeutic context of Substance-Related Disorders


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  2. Botulism and botulism-like illness in chronic drug abusers. MacDonald, K.L., Rutherford, G.W., Friedman, S.M., Dietz, J.R., Kaye, B.R., McKinley, G.F., Tenney, J.H., Cohen, M.L. Ann. Intern. Med. (1985) [Pubmed]
  3. Adherence and mental side effects during hepatitis C treatment with interferon alfa and ribavirin in psychiatric risk groups. Schaefer, M., Schmidt, F., Folwaczny, C., Lorenz, R., Martin, G., Schindlbeck, N., Heldwein, W., Soyka, M., Grunze, H., Koenig, A., Loeschke, K. Hepatology (2003) [Pubmed]
  4. Changes in nongonococcal septic arthritis: drug abuse and methicillin-resistant Staphylococcus aureus. Ang-Fonte, G.Z., Rozboril, M.B., Thompson, G.R. Arthritis Rheum. (1985) [Pubmed]
  5. Longitudinal assessment of the effects of drug and alcohol abuse on HIV-1 treatment outcomes in an urban clinic. Lucas, G.M., Gebo, K.A., Chaisson, R.E., Moore, R.D. AIDS (2002) [Pubmed]
  6. Rebound insomnia. A potential hazard following withdrawal of certain benzodiazepines. Kales, A., Scharf, M.B., Kales, J.D., Soldatos, C.R. JAMA (1979) [Pubmed]
  7. Cigarette smoking. Bergen, A.W., Caporaso, N. J. Natl. Cancer Inst. (1999) [Pubmed]
  8. Prevalence and development of psychiatric disorders in childhood and adolescence. Costello, E.J., Mustillo, S., Erkanli, A., Keeler, G., Angold, A. Arch. Gen. Psychiatry (2003) [Pubmed]
  9. Mortality in a follow-up of 500 psychiatric outpatients. II. Cause-specific mortality. Martin, R.L., Cloninger, C.R., Guze, S.B., Clayton, P.J. Arch. Gen. Psychiatry (1985) [Pubmed]
  10. Epidemiology of major depressive disorder: results from the National Epidemiologic Survey on Alcoholism and Related Conditions. Hasin, D.S., Goodwin, R.D., Stinson, F.S., Grant, B.F. Arch. Gen. Psychiatry (2005) [Pubmed]
  11. Mice deficient for delta- and mu-opioid receptors exhibit opposing alterations of emotional responses. Filliol, D., Ghozland, S., Chluba, J., Martin, M., Matthes, H.W., Simonin, F., Befort, K., Gavériaux-Ruff, C., Dierich, A., LeMeur, M., Valverde, O., Maldonado, R., Kieffer, B.L. Nat. Genet. (2000) [Pubmed]
  12. Violent injuries among women in an urban area. Grisso, J.A., Schwarz, D.F., Hirschinger, N., Sammel, M., Brensinger, C., Santanna, J., Lowe, R.A., Anderson, E., Shaw, L.M., Bethel, C.A., Teeple, L. N. Engl. J. Med. (1999) [Pubmed]
  13. Impaired stress response and reduced anxiety in mice lacking a functional corticotropin-releasing hormone receptor 1. Timpl, P., Spanagel, R., Sillaber, I., Kresse, A., Reul, J.M., Stalla, G.K., Blanquet, V., Steckler, T., Holsboer, F., Wurst, W. Nat. Genet. (1998) [Pubmed]
  14. Subsecond dopamine release promotes cocaine seeking. Phillips, P.E., Stuber, G.D., Heien, M.L., Wightman, R.M., Carelli, R.M. Nature (2003) [Pubmed]
  15. Rewarding effects of opiates are absent in mice lacking the receptor for substance P. Murtra, P., Sheasby, A.M., Hunt, S.P., De Felipe, C. Nature (2000) [Pubmed]
  16. Selective inhibition of cocaine-seeking behaviour by a partial dopamine D3 receptor agonist. Pilla, M., Perachon, S., Sautel, F., Garrido, F., Mann, A., Wermuth, C.G., Schwartz, J.C., Everitt, B.J., Sokoloff, P. Nature (1999) [Pubmed]
  17. Moderate- vs high-dose methadone in the treatment of opioid dependence: a randomized trial. Strain, E.C., Bigelow, G.E., Liebson, I.A., Stitzer, M.L. JAMA (1999) [Pubmed]
  18. Beneficial effects of treatment of nicotine dependence during an inpatient substance abuse treatment program. Joseph, A.M., Nichol, K.L., Willenbring, M.L., Korn, J.E., Lysaght, L.S. JAMA (1990) [Pubmed]
  19. The definition of alcoholism. The Joint Committee of the National Council on Alcoholism and Drug Dependence and the American Society of Addiction Medicine to Study the Definition and Criteria for the Diagnosis of Alcoholism. Morse, R.M., Flavin, D.K. JAMA (1992) [Pubmed]
  20. Caffeine dependence syndrome. Evidence from case histories and experimental evaluations. Strain, E.C., Mumford, G.K., Silverman, K., Griffiths, R.R. JAMA (1994) [Pubmed]
  21. Genetic vulnerability to drug abuse. The D2 dopamine receptor Taq I B1 restriction fragment length polymorphism appears more frequently in polysubstance abusers. Smith, S.S., O'Hara, B.F., Persico, A.M., Gorelick, D.A., Newlin, D.B., Vlahov, D., Solomon, L., Pickens, R., Uhl, G.R. Arch. Gen. Psychiatry (1992) [Pubmed]
  22. Chromosomes in patients receiving methadone and methadyl acetate. Matsuyama, S.S., Charuvastra, V.C., Jarvik, L.F., Fu, T.K., Sanders, K., Yen, F.S. Arch. Gen. Psychiatry (1978) [Pubmed]
  23. A dopamine transporter gene functional variant associated with cocaine abuse in a Brazilian sample. Guindalini, C., Howard, M., Haddley, K., Laranjeira, R., Collier, D., Ammar, N., Craig, I., O'Gara, C., Bubb, V.J., Greenwood, T., Kelsoe, J., Asherson, P., Murray, R.M., Castelo, A., Quinn, J.P., Vallada, H., Breen, G. Proc. Natl. Acad. Sci. U.S.A. (2006) [Pubmed]
  24. Depolarization strongly induces human cytomegalovirus major immediate-early promoter/enhancer activity in neurons. Wheeler, D.G., Cooper, E. J. Biol. Chem. (2001) [Pubmed]
  25. Allelic expression imbalance of human mu opioid receptor (OPRM1) caused by variant A118G. Zhang, Y., Wang, D., Johnson, A.D., Papp, A.C., Sadée, W. J. Biol. Chem. (2005) [Pubmed]
  26. Activation of corticotropin-releasing factor in the limbic system during cannabinoid withdrawal. Rodríguez de Fonseca, F., Carrera, M.R., Navarro, M., Koob, G.F., Weiss, F. Science (1997) [Pubmed]
  27. The many faces of CREB. Carlezon, W.A., Duman, R.S., Nestler, E.J. Trends Neurosci. (2005) [Pubmed]
  28. Familial variation in episode frequency in bipolar affective disorder. Fisfalen, M.E., Schulze, T.G., DePaulo, J.R., DeGroot, L.J., Badner, J.A., McMahon, F.J. The American journal of psychiatry. (2005) [Pubmed]
  29. Metabolite alterations in basal ganglia associated with psychiatric symptoms of abstinent toluene users: a proton MRS study. Takebayashi, K., Sekine, Y., Takei, N., Minabe, Y., Isoda, H., Takeda, H., Nishimura, K., Nakamura, K., Suzuki, K., Iwata, Y., Sakahara, H., Mori, N. Neuropsychopharmacology (2004) [Pubmed]
  30. Risk factors for extrapyramidal symptoms during treatment with selective serotonin reuptake inhibitors, including cytochrome P-450 enzyme, and serotonin and dopamine transporter and receptor polymorphisms. Hedenmalm, K., Güzey, C., Dahl, M.L., Yue, Q.Y., Spigset, O. Journal of clinical psychopharmacology. (2006) [Pubmed]
  31. Mpdz is a quantitative trait gene for drug withdrawal seizures. Shirley, R.L., Walter, N.A., Reilly, M.T., Fehr, C., Buck, K.J. Nat. Neurosci. (2004) [Pubmed]
  32. Knockout of ERK1 MAP kinase enhances synaptic plasticity in the striatum and facilitates striatal-mediated learning and memory. Mazzucchelli, C., Vantaggiato, C., Ciamei, A., Fasano, S., Pakhotin, P., Krezel, W., Welzl, H., Wolfer, D.P., Pagès, G., Valverde, O., Marowsky, A., Porrazzo, A., Orban, P.C., Maldonado, R., Ehrengruber, M.U., Cestari, V., Lipp, H.P., Chapman, P.F., Pouysségur, J., Brambilla, R. Neuron (2002) [Pubmed]
  33. Dopamine-dependent responses to morphine depend on glucocorticoid receptors. Marinelli, M., Aouizerate, B., Barrot, M., Le Moal, M., Piazza, P.V. Proc. Natl. Acad. Sci. U.S.A. (1998) [Pubmed]
  34. Cocaine sensitization and reward are under the influence of circadian genes and rhythm. Abarca, C., Albrecht, U., Spanagel, R. Proc. Natl. Acad. Sci. U.S.A. (2002) [Pubmed]
  35. Reduced cellular expression and activity of the P129T mutant of human fatty acid amide hydrolase: evidence for a link between defects in the endocannabinoid system and problem drug use. Chiang, K.P., Gerber, A.L., Sipe, J.C., Cravatt, B.F. Hum. Mol. Genet. (2004) [Pubmed]
  36. Effects of lower-cost incentives on stimulant abstinence in methadone maintenance treatment: a National Drug Abuse Treatment Clinical Trials Network study. Peirce, J.M., Petry, N.M., Stitzer, M.L., Blaine, J., Kellogg, S., Satterfield, F., Schwartz, M., Krasnansky, J., Pencer, E., Silva-Vazquez, L., Kirby, K.C., Royer-Malvestuto, C., Roll, J.M., Cohen, A., Copersino, M.L., Kolodner, K., Li, R. Arch. Gen. Psychiatry (2006) [Pubmed]
  37. Differential binding of tropane-based photoaffinity ligands on the dopamine transporter. Vaughan, R.A., Agoston, G.E., Lever, J.R., Newman, A.H. J. Neurosci. (1999) [Pubmed]
  38. The acquired immune deficiency syndrome (AIDS) and suicidal behavior in alcohol-dependent homosexual men. Flavin, D.K., Franklin, J.E., Frances, R.J. The American journal of psychiatry. (1986) [Pubmed]
  39. Single photon emission computed tomography in phencyclidine and related drug abuse. Hertzmann, M., Reba, R.C., Kotlyarov, E.V. The American journal of psychiatry. (1990) [Pubmed]
  40. Accelerated development of pulmonary complications due to illicit intravenous use of pentazocine and tripelennamine. Itkonen, J., Schnoll, S., Daghestani, A., Glassroth, J. Am. J. Med. (1984) [Pubmed]
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