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MeSH Review

Transducers

 
 
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Disease relevance of Transducers

 

Psychiatry related information on Transducers

 

High impact information on Transducers

  • The SOCS proteins also appear to target signal transducers for proteasomal destruction [9].
  • The pathway uses a novel mechanism in which cytosolic latent transcription factors, known as signal transducers and activators of transcription (STATs), are tyrosine phosphorylated by Janus family tyrosine kinases (Jaks), allowing STAT protein dimerization and nuclear translocation [10].
  • Using a functional definition of signaling elements, we discuss the current knowledge of signaling events from the BCR and suggest the existence of an as-yet-unknown BCR transducer complex [11].
  • Characterization of the ability of IFN-alpha to rapidly induce new genes has led to the identification of a new signaling paradigm, the JAK-STAT (Signal Transducers and Activators of Transcription) pathway [12].
  • Depending on the specific serine residues dephosphorylated by PAPP5, phytochrome stability and affinity for a downstream signal transducer, NDPK2, were enhanced [13].
 

Chemical compound and disease context of Transducers

 

Biological context of Transducers

 

Anatomical context of Transducers

 

Associations of Transducers with chemical compounds

 

Gene context of Transducers

  • TRADD is a TNFR1-associated signal transducer that is involved in activating both pathways [30].
  • TRAF6 is a signal transducer in the NF-kappaB pathway that activates IkappaB kinase (IKK) in response to proinflammatory cytokines [31].
  • Two other signal transducers, RIP and TRAF2, mediate both JNK and NF-kappaB activation [18].
  • Two of these signal transducers, TRAF1 and TRAF2, were isolated and characterized previously [32].
  • Previously known as the ultimate recipients of cdk regulatory signals, E2F4/5 and p107 act here as transducers of TGFbeta receptor signals upstream of cdk [33].
 

Analytical, diagnostic and therapeutic context of Transducers

References

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  28. Direct stimulation of Jak/STAT pathway by the angiotensin II AT1 receptor. Marrero, M.B., Schieffer, B., Paxton, W.G., Heerdt, L., Berk, B.C., Delafontaine, P., Bernstein, K.E. Nature (1995) [Pubmed]
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