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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
MeSH Review

Dyslexia

 
 
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Disease relevance of Dyslexia

 

Psychiatry related information on Dyslexia

 

High impact information on Dyslexia

 

Chemical compound and disease context of Dyslexia

  • Brains from male cases with dyslexia show symmetry of the planum temporale and predominantly left-sided cerebrocortical microdysgenesis [14].
  • The effects of piracetam in children with dyslexia [15].
  • These findings are discussed in light of Geschwind's hypothesis of a testosterone-mediated association within families between left-handedness, immune disorders, and dyslexia [16].
  • The choice of imaging planes (particularly coronal) and lack of bone artifact may, however, prove useful for studying macroscopic asymmetries in dyslexia [17].
  • Regional cerebral blood flow was measured under three task conditions in 14 men with severe developmental dyslexia and their control subjects using a xenon 133 inhalation technique [18].
 

Biological context of Dyslexia

  • These data suggest a direct link between a specific genetic background and a biological mechanism leading to the development of dyslexia: the risk haplotype on chromosome 6p22.2 down-regulates the KIAA0319 gene which is required for neuronal migration during the formation of the cerebral neocortex [19].
  • We conclude that the polymorphisms identified in the Finland sample are unlikely to be functional DNA changes contributing to dyslexia, and that if variation in EKN1 is causal such changes are more likely to be in regulatory regions that were not sequenced in this study [20].
  • We studied auditory event-related potentials (ERP) in newborns and 6-month-old infants, about half of whom had a familial risk for dyslexia [21].
  • Among five "backcross families" studied for chromosome 15 polymorphisms we found only negative lod scores, and at theta = 0.10 a negative score of -3.42; i.e., in our material we did not find any confirmation of the indication of linkage between dyslexia and a chromosome 15 polymorphism found in part of their material by Smith et al [22].
  • Early alexia and higher visual impairments characterize Posterior cortical atrophy (PCA), a progressive dementing syndrome most often caused by Alzheimer disease [23].
 

Anatomical context of Dyslexia

  • OBJECTIVE: To examine the size and asymmetry of the PT and its extension into the parietal lobe (planum parietale [PP]) in men with well-characterized, persistent dyslexia by using magnetic resonance imaging and 3-dimensional surface rendering techniques [24].
 

Gene context of Dyslexia

  • We conclude that DYX1C1 should be regarded as a candidate gene for developmental dyslexia [25].
  • Analyses of FOXP2 coding sequence in typical forms of specific language impairment (SLI), autism, and dyslexia have not uncovered any etiological variants [26].
  • Possible localisations of genes for dyslexia have been reported on chromosomes 15 (DYX1), 6p21.3-23 (DYX2), and 1p over the last 15 years [27].
  • 5. Using 100 families having at least two siblings affected with dyslexia, model-free linkage analysis revealed evidence for linkage to the DRD4-exon 3 repeat (two-point MFLOD = 2.27, P = 0.001) and to HRAS located just proximal to DRD4 (two-point MFLOD = 2.68, P = 0.0004) [28].
  • Supportive evidence for the DYX3 dyslexia susceptibility gene in Canadian families [29].
 

Analytical, diagnostic and therapeutic context of Dyslexia

References

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  2. Auditory event-related potentials in the study of developmental language-related disorders. Leppänen, P.H., Lyytinen, H. Audiol. Neurootol. (1997) [Pubmed]
  3. The nonword reading deficit in developmental dyslexia: evidence from children learning to read German. Wimmer, H. Journal of experimental child psychology. (1996) [Pubmed]
  4. Dyslexia and familial high blood pressure: an observational pilot study. Taylor, K., Stein, J. Arch. Dis. Child. (2002) [Pubmed]
  5. Enterocolitis in children with developmental disorders. Wakefield, A.J., Anthony, A., Murch, S.H., Thomson, M., Montgomery, S.M., Davies, S., O'Leary, J.J., Berelowitz, M., Walker-Smith, J.A. Am. J. Gastroenterol. (2000) [Pubmed]
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  7. Clinical trials of fatty acid treatment in ADHD, dyslexia, dyspraxia and the autistic spectrum. Richardson, A.J. Prostaglandins Leukot. Essent. Fatty Acids (2004) [Pubmed]
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  12. Strong genetic evidence of DCDC2 as a susceptibility gene for dyslexia. Schumacher, J., Anthoni, H., Dahdouh, F., König, I.R., Hillmer, A.M., Kluck, N., Manthey, M., Plume, E., Warnke, A., Remschmidt, H., Hülsmann, J., Cichon, S., Lindgren, C.M., Propping, P., Zucchelli, M., Ziegler, A., Peyrard-Janvid, M., Schulte-Körne, G., Nöthen, M.M., Kere, J. Am. J. Hum. Genet. (2006) [Pubmed]
  13. Strong evidence that KIAA0319 on chromosome 6p is a susceptibility gene for developmental dyslexia. Cope, N., Harold, D., Hill, G., Moskvina, V., Stevenson, J., Holmans, P., Owen, M.J., O'Donovan, M.C., Williams, J. Am. J. Hum. Genet. (2005) [Pubmed]
  14. Developmental dyslexia in women: neuropathological findings in three patients. Humphreys, P., Kaufmann, W.E., Galaburda, A.M. Ann. Neurol. (1990) [Pubmed]
  15. The effects of piracetam in children with dyslexia. Di Ianni, M., Wilsher, C.R., Blank, M.S., Conners, C.K., Chase, C.H., Funkenstein, H.H., Helfgott, E., Holmes, J.M., Lougee, L., Maletta, G.J. Journal of clinical psychopharmacology. (1985) [Pubmed]
  16. Left-handedness and immune disorders in familial dyslexics. Pennington, B.F., Smith, S.D., Kimberling, W.J., Green, P.A., Haith, M.M. Arch. Neurol. (1987) [Pubmed]
  17. Magnetic resonance imaging of brain anatomy in severe developmental dyslexia. Rumsey, J.M., Dorwart, R., Vermess, M., Denckla, M.B., Kruesi, M.J., Rapoport, J.L. Arch. Neurol. (1986) [Pubmed]
  18. Regional cerebral blood flow in severe developmental dyslexia. Rumsey, J.M., Berman, K.F., Denckla, M.B., Hamburger, S.D., Kruesi, M.J., Weinberger, D.R. Arch. Neurol. (1987) [Pubmed]
  19. The chromosome 6p22 haplotype associated with dyslexia reduces the expression of KIAA0319, a novel gene involved in neuronal migration. Paracchini, S., Thomas, A., Castro, S., Lai, C., Paramasivam, M., Wang, Y., Keating, B.J., Taylor, J.M., Hacking, D.F., Scerri, T., Francks, C., Richardson, A.J., Wade-Martins, R., Stein, J.F., Knight, J.C., Copp, A.J., Loturco, J., Monaco, A.P. Hum. Mol. Genet. (2006) [Pubmed]
  20. TDT-association analysis of EKN1 and dyslexia in a Colorado twin cohort. Meng, H., Hager, K., Held, M., Page, G.P., Olson, R.K., Pennington, B.F., Defries, J.C., Smith, S.D., Gruen, J.R. Hum. Genet. (2005) [Pubmed]
  21. Cortical responses of infants with and without a genetic risk for dyslexia: I. Age effects. Pihko, E., Leppänen, P.H., Eklund, K.M., Cheour, M., Guttorm, T.K., Lyytinen, H. Neuroreport (1999) [Pubmed]
  22. Dyslexia and chromosome 15 heteromorphism: negative lod score in a Danish material. Bisgaard, M.L., Eiberg, H., Møller, N., Niebuhr, E., Mohr, J. Clin. Genet. (1987) [Pubmed]
  23. The evolution of alexia and simultanagnosia in posterior cortical atrophy. Mendez, M.F., Cherrier, M.M. Neuropsychiatry, neuropsychology, and behavioral neurology. (1998) [Pubmed]
  24. A magnetic resonance imaging study of planum temporale asymmetry in men with developmental dyslexia. Rumsey, J.M., Donohue, B.C., Brady, D.R., Nace, K., Giedd, J.N., Andreason, P. Arch. Neurol. (1997) [Pubmed]
  25. A candidate gene for developmental dyslexia encodes a nuclear tetratricopeptide repeat domain protein dynamically regulated in brain. Taipale, M., Kaminen, N., Nopola-Hemmi, J., Haltia, T., Myllyluoma, B., Lyytinen, H., Muller, K., Kaaranen, M., Lindsberg, P.J., Hannula-Jouppi, K., Kere, J. Proc. Natl. Acad. Sci. U.S.A. (2003) [Pubmed]
  26. Identification of FOXP2 truncation as a novel cause of developmental speech and language deficits. MacDermot, K.D., Bonora, E., Sykes, N., Coupe, A.M., Lai, C.S., Vernes, S.C., Vargha-Khadem, F., McKenzie, F., Smith, R.L., Monaco, A.P., Fisher, S.E. Am. J. Hum. Genet. (2005) [Pubmed]
  27. A new gene (DYX3) for dyslexia is located on chromosome 2. Fagerheim, T., Raeymaekers, P., Tønnessen, F.E., Pedersen, M., Tranebjaerg, L., Lubs, H.A. J. Med. Genet. (1999) [Pubmed]
  28. A dyslexia susceptibility locus (DYX7) linked to dopamine D4 receptor (DRD4) region on chromosome 11p15.5. Hsiung, G.Y., Kaplan, B.J., Petryshen, T.L., Lu, S., Field, L.L. Am. J. Med. Genet. B Neuropsychiatr. Genet. (2004) [Pubmed]
  29. Supportive evidence for the DYX3 dyslexia susceptibility gene in Canadian families. Petryshen, T.L., Kaplan, B.J., Hughes, M.L., Tzenova, J., Field, L.L. J. Med. Genet. (2002) [Pubmed]
  30. A twin study of the etiology of comorbidity: attention-deficit hyperactivity disorder and dyslexia. Gilger, J.W., Pennington, B.F., DeFries, J.C. Journal of the American Academy of Child and Adolescent Psychiatry. (1992) [Pubmed]
  31. The child with developmental disabilities grown up: adult residua of childhood disorders. Denckla, M.B. Neurologic clinics. (1993) [Pubmed]
  32. Scalp potentials evoked by amplitude-modulated tones in dyslexia. McAnally, K.I., Stein, J.F. J. Speech Lang. Hear. Res. (1997) [Pubmed]
  33. Measurement mischief: a critique of Reynolds, Nicolson and Hambly (2003). Singleton, C., Stuart, M. Dyslexia (Chichester, England) (2003) [Pubmed]
 
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