The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
MeSH Review

Pseudorabies

 
 
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.
 

Disease relevance of Pseudorabies

 

High impact information on Pseudorabies

  • Injection of conditional pseudorabies virus into the brain of an LHRH::CRE mouse line led to the identification of neuronal networks connected to LHRH neurons [6].
  • In vitro stimulation of specific RNA polymerase II-mediated transcription by the pseudorabies virus immediate early protein [7].
  • The pseudorabies immediate early protein stimulates in vitro transcription by facilitating TFIID: promoter interactions [8].
  • Uptake and transneuronal passage of wild-type and attenuated strains of a swine alpha-herpesvirus (pseudorabies [PRV]) were examined in rat visual projections [9].
  • This study determined the presence of nitric oxide synthase in the brain stem circuit controlling esophageal peristalsis by combining transsynaptic retrograde tract tracing with pseudorabies virus and nicotinamide adenine dinucleotide phosphate diaphorase (NADPH) histochemistry [10].
 

Chemical compound and disease context of Pseudorabies

  • The induction by pseudorabies virus of an IL-6 construct containing the IL-6 TATA box and the RNA start site ("initiator" or Inr element) but not the MRE region was also repressed by Dex in the presence of wild-type GR [11].
  • Interaction between pseudorabies virus and heparin/heparan sulfate. Pseudorabies virus mutants differ in their interaction with heparin/heparan sulfate when altered for specific glycoprotein C heparin-binding domain [12].
  • To address the conformational constraints of a eukaryotic signal sequence, we have introduced a single proline in almost each position of the signal sequence hydrophobic core of glycoprotein C (gC) of the swine herpesvirus, pseudorabies virus [13].
  • The ability of the UL region to invert itself is probably related to the fact that a sequence normally present in all other pseudorabies virus strains at the end of the UL only is found also in inverted form at the junction of the UL and the internal inverted repeat in the Norden strain [14].
  • A tyrosine-based motif in the cytoplasmic tail of pseudorabies virus glycoprotein B is important for both antibody-induced internalization of viral glycoproteins and efficient cell-to-cell spread [15].
 

Biological context of Pseudorabies

 

Anatomical context of Pseudorabies

 

Gene context of Pseudorabies

 

Analytical, diagnostic and therapeutic context of Pseudorabies

References

  1. Transcriptional activation of cloned human beta-globin genes by viral immediate-early gene products. Green, M.R., Treisman, R., Maniatis, T. Cell (1983) [Pubmed]
  2. Use of herpes simplex virus and pseudorabies virus chimeric glycoprotein D molecules to identify regions critical for membrane fusion. Zago, A., Jogger, C.R., Spear, P.G. Proc. Natl. Acad. Sci. U.S.A. (2004) [Pubmed]
  3. Role of the cytoplasmic tail of pseudorabies virus glycoprotein E in virion formation. Brack, A.R., Klupp, B.G., Granzow, H., Tirabassi, R., Enquist, L.W., Mettenleiter, T.C. J. Virol. (2000) [Pubmed]
  4. Pseudorabies virus glycoprotein L is necessary for virus infectivity but dispensable for virion localization of glycoprotein H. Klupp, B.G., Fuchs, W., Weiland, E., Mettenleiter, T.C. J. Virol. (1997) [Pubmed]
  5. Bovine cells expressing bovine herpesvirus 1 (BHV-1) glycoprotein IV resist infection by BHV-1, herpes simplex virus, and pseudorabies virus. Chase, C.C., Carter-Allen, K., Lohff, C., Letchworth, G.J. J. Virol. (1990) [Pubmed]
  6. Olfactory inputs to hypothalamic neurons controlling reproduction and fertility. Yoon, H., Enquist, L.W., Dulac, C. Cell (2005) [Pubmed]
  7. In vitro stimulation of specific RNA polymerase II-mediated transcription by the pseudorabies virus immediate early protein. Abmayr, S.M., Feldman, L.D., Roeder, R.G. Cell (1985) [Pubmed]
  8. The pseudorabies immediate early protein stimulates in vitro transcription by facilitating TFIID: promoter interactions. Abmayr, S.M., Workman, J.L., Roeder, R.G. Genes Dev. (1988) [Pubmed]
  9. Two alpha-herpesvirus strains are transported differentially in the rodent visual system. Card, J.P., Whealy, M.E., Robbins, A.K., Moore, R.Y., Enquist, L.W. Neuron (1991) [Pubmed]
  10. Localization of nitric oxide synthase in the brain stem neural circuit controlling esophageal peristalsis in rats. Wiedner, E.B., Bao, X., Altschuler, S.M. Gastroenterology (1995) [Pubmed]
  11. On the mechanism for efficient repression of the interleukin-6 promoter by glucocorticoids: enhancer, TATA box, and RNA start site (Inr motif) occlusion. Ray, A., LaForge, K.S., Sehgal, P.B. Mol. Cell. Biol. (1990) [Pubmed]
  12. Interaction between pseudorabies virus and heparin/heparan sulfate. Pseudorabies virus mutants differ in their interaction with heparin/heparan sulfate when altered for specific glycoprotein C heparin-binding domain. Trybala, E., Bergström, T., Spillmann, D., Svennerholm, B., Flynn, S.J., Ryan, P. J. Biol. Chem. (1998) [Pubmed]
  13. Systematic introduction of proline in a eukaryotic signal sequence suggests asymmetry within the hydrophobic core. Ryan, P., Edwards, C.O. J. Biol. Chem. (1995) [Pubmed]
  14. Deletions in the genomes of pseudorabies virus vaccine strains and existence of four isomers of the genomes. Lomniczi, B., Blankenship, M.L., Ben-Porat, T. J. Virol. (1984) [Pubmed]
  15. A tyrosine-based motif in the cytoplasmic tail of pseudorabies virus glycoprotein B is important for both antibody-induced internalization of viral glycoproteins and efficient cell-to-cell spread. Favoreel, H.W., Van Minnebruggen, G., Nauwynck, H.J., Enquist, L.W., Pensaert, M.B. J. Virol. (2002) [Pubmed]
  16. Role of a structural glycoprotein of pseudorabies in virus virulence. Mettenleiter, T.C., Zsak, L., Kaplan, A.S., Ben-Porat, T., Lomniczi, B. J. Virol. (1987) [Pubmed]
  17. Proteins specified by the short unique region of the genome of pseudorabies virus play a role in the release of virions from certain cells. Ben-Porat, T., DeMarchi, J., Pendrys, J., Veach, R.A., Kaplan, A.S. J. Virol. (1986) [Pubmed]
  18. DNA sequence of the gene for pseudorabies virus gp50, a glycoprotein without N-linked glycosylation. Petrovskis, E.A., Timmins, J.G., Armentrout, M.A., Marchioli, C.C., Yancey, R.J., Post, L.E. J. Virol. (1986) [Pubmed]
  19. Glycoprotein D-negative pseudorabies virus can spread transneuronally via direct neuron-to-neuron transmission in its natural host, the pig, but not after additional inactivation of gE or gI. Mulder, W., Pol, J., Kimman, T., Kok, G., Priem, J., Peeters, B. J. Virol. (1996) [Pubmed]
  20. The attenuated pseudorabies virus strain Bartha fails to package the tegument proteins Us3 and VP22. Lyman, M.G., Demmin, G.L., Banfield, B.W. J. Virol. (2003) [Pubmed]
  21. A novel strategy for defining critical amino acid residues involved in protein/glycosaminoglycan interactions. Vivès, R.R., Crublet, E., Andrieu, J.P., Gagnon, J., Rousselle, P., Lortat-Jacob, H. J. Biol. Chem. (2004) [Pubmed]
  22. A major portion of the latent pseudorabies virus genome is transcribed in trigeminal ganglia of pigs. Priola, S.A., Gustafson, D.P., Wagner, E.K., Stevens, J.G. J. Virol. (1990) [Pubmed]
  23. Circuit-specific coinfection of neurons in the rat central nervous system with two pseudorabies virus recombinants. Kim, J.S., Enquist, L.W., Card, J.P. J. Virol. (1999) [Pubmed]
  24. The amino-terminal one-third of pseudorabies virus glycoprotein gIII contains a functional attachment domain, but this domain is not required for the efficient penetration of Vero cells. Flynn, S.J., Burgett, B.L., Stein, D.S., Wilkinson, K.S., Ryan, P. J. Virol. (1993) [Pubmed]
  25. Pseudorabies virus UL37 gene product is involved in secondary envelopment. Klupp, B.G., Granzow, H., Mundt, E., Mettenleiter, T.C. J. Virol. (2001) [Pubmed]
  26. Functional analysis of the pseudorabies virus UL51 protein. Klupp, B.G., Granzow, H., Klopfleisch, R., Fuchs, W., Kopp, M., Lenk, M., Mettenleiter, T.C. J. Virol. (2005) [Pubmed]
  27. Identification and characterization of pseudorabies virus dUTPase. Jöns, A., Mettenleiter, T.C. J. Virol. (1996) [Pubmed]
  28. Cloning, sequencing, and functional characterization of the two subunits of the pseudorabies virus DNA polymerase holoenzyme: evidence for specificity of interaction. Berthomme, H., Monahan, S.J., Parris, D.S., Jacquemont, B., Epstein, A.L. J. Virol. (1995) [Pubmed]
  29. The UL49.5 gene of pseudorabies virus codes for an O-glycosylated structural protein of the viral envelope. Jöns, A., Granzow, H., Kuchling, R., Mettenleiter, T.C. J. Virol. (1996) [Pubmed]
  30. Protective antiviral immune responses to pseudorabies virus induced by DNA vaccination using dimethyldioctadecylammonium bromide as an adjuvant. van Rooij, E.M., Glansbeek, H.L., Hilgers, L.A., te Lintelo, E.G., de Visser, Y.E., Boersma, W.J., Haagmans, B.L., Bianchi, A.T. J. Virol. (2002) [Pubmed]
  31. Glycoprotein gp50-negative pseudorabies virus: a novel approach toward a nonspreading live herpesvirus vaccine. Heffner, S., Kovács, F., Klupp, B.G., Mettenleiter, T.C. J. Virol. (1993) [Pubmed]
  32. Processing of pseudorabies virus glycoprotein gII. Wölfer, U., Kruft, V., Sawitzky, D., Hampl, H., Wittmann-Liebold, B., Habermehl, K.O. J. Virol. (1990) [Pubmed]
  33. The pseudorabies virus UL28 protein enters the nucleus after coexpression with the herpes simplex virus UL15 protein. Koslowski, K.M., Shaver, P.R., Wang, X.Y., Tenney, D.J., Pederson, N.E. J. Virol. (1997) [Pubmed]
 
WikiGenes - Universities