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MeSH Review

Heart Septal Defects, Atrial

 
 
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Disease relevance of Heart Septal Defects, Atrial

 

High impact information on Heart Septal Defects, Atrial

 

Chemical compound and disease context of Heart Septal Defects, Atrial

  • METHODS: The Patent foramen ovale In Cryptogenic Stroke Study (PICSS) evaluated transesophageal echocardiography findings in patients enrolled in the Warfarin-Aspirin Recurrent Stroke Study, a randomized double-blind trial to evaluate the efficacy of warfarin compared with aspirin [11].
  • The defects were easily visualized in all patients using a long axis vena cava superior-inferior plane with a subcostal approach, while the atrial septum seemed to be intact in the coronal plane conventionally used for atrial septal defects of the primum or secundum type [12].
  • This laser catheter system, capable of transmitting several watts of pulsed CO2 laser energy, was initially used to create atrial septal defects in isolated dog hearts to determine the best energy parameters [13].
  • BACKGROUND: Aspirin has been routinely prescribed following transcatheter closure of secundum atrial septal defects (ASDs) but its rationale has not been clinically or biologically evaluated; and despite aspirin, thrombotic complications occur following transcatheter ASD closure [14].
  • Cerebro- and cardiovascular workup, however, led to a diagnosis of paradoxical cardioembolic stroke through a patent foramen ovale [15].
 

Biological context of Heart Septal Defects, Atrial

 

Anatomical context of Heart Septal Defects, Atrial

 

Gene context of Heart Septal Defects, Atrial

  • The cardiac transcription factor GATA4 has not previously been implicated in a human disorder but a recent paper by Garg et al. provides evidence of mutations in GATA4 that cause atrial septal defects [26].
  • Mutations in TBX5 have already been shown to cause similar atrial septal defects in Holt-Oram syndrome [26].
  • Further trends towards higher frequencies of the FVL mutation were found in patients with patent foramen ovale (OR 1.9), individual (OR 2.1) or family history of previous thrombembolisms (OR 2.0), and in those aged 25 years at onset of disease (OR 1.9, all not significant) [27].
  • Although ASD occurred only rarely, atrial septal dysmorphogenesis was evident as increased frequencies of patent foramen ovale and septal aneurysm, and decreased length of the septum primum flap valve [28].
  • Transcatheter closure of atrial septal defects. Past, present, and future [29].
 

Analytical, diagnostic and therapeutic context of Heart Septal Defects, Atrial

References

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