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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review


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Disease relevance of Retroviridae


Psychiatry related information on Retroviridae


High impact information on Retroviridae

  • To determine whether Rb functions in these processes in a cell-autonomous manner, we used a replication-incompetent retrovirus encoding Cre recombinase to inactivate the Rb1(lox) allele in individual retinal progenitor cells in vivo [9].
  • A natural allele of Nxf1 suppresses retrovirus insertional mutations [10].
  • Insertional mutagenesis by the latent retrovirus was synergistic with loss of Cdkn2a expression, as indicated by a marked acceleration in the development of both myeloid and lymphoid tumors [11].
  • An ex vivo approach to gene therapy for familial hypercholesterolaemia (FH) has been developed in which the recipient is transplanted with autologous hepatocytes that are genetically corrected with recombinant retroviruses carrying the LDL receptor [12].
  • Using a retrovirus construct modified to express BCR-ABL and MYC genes simultaneously, we show that dominant negative MYC suppressed transformation of primary mouse bone marrow pre-B cells by BCR-ABL [13].

Chemical compound and disease context of Retroviridae


Biological context of Retroviridae


Anatomical context of Retroviridae


Gene context of Retroviridae

  • When placed under the control of a retrovirus LTR, the clone was transcribed at levels comparable to that observed in cells transformed by SSV DNA [29].
  • Fibroblast cells overexpressing the LYAR cDNA from a retrovirus vector, though not phenotypically transformed in vitro, had increased ability to form tumors in nu/nu mice [30].
  • In addition, using a self-inactivating retrovirus luciferase reporter construct we showed that TGF-beta1 induces Smad4, which then binds to and activates the IL-10 promoter [31].
  • A retrovirus encoding polyoma middle T antigen has been used to infect a murine hemopoietic cell line (FDC-P1) dependent on either granulocyte-macrophage colony-stimulating factor (GM-CSF) or multipotential colony-stimulating factor (Multi-CSF) [32].
  • Infection of TF-1 cells with a retrovirus containing a normal murine EpoR was able to restore both Epo-induced STAT5 activity and cellular proliferation [33].

Analytical, diagnostic and therapeutic context of Retroviridae


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  3. Murine T lymphomas in which the cellular myc oncogene has been activated by retroviral insertion. Corcoran, L.M., Adams, J.M., Dunn, A.R., Cory, S. Cell (1984) [Pubmed]
  4. Characterization of ribosomal frameshifting in HIV-1 gag-pol expression. Jacks, T., Power, M.D., Masiarz, F.R., Luciw, P.A., Barr, P.J., Varmus, H.E. Nature (1988) [Pubmed]
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  6. Endogenous viral complexes with long RNA cosediment with the agent of Creutzfeldt-Jakob disease. Akowitz, A., Sklaviadis, T., Manuelidis, L. Nucleic Acids Res. (1994) [Pubmed]
  7. Exogenous mouse mammary tumor virus proviral DNA isolated from a kidney adenocarcinoma cell line contains alterations in the U3 region of the long terminal repeat. Wellinger, R.J., Garcia, M., Vessaz, A., Diggelmann, H. J. Virol. (1986) [Pubmed]
  8. Localization of retrovirus in the central nervous system of a patient co-infected with HTLV-1 and HIV with HAM/TSP and HIV-associated dementia. Levin, M.C., Rosenblum, M.K., Fox, C.H., Jacobson, S. J. Neurovirol. (2001) [Pubmed]
  9. Rb regulates proliferation and rod photoreceptor development in the mouse retina. Zhang, J., Gray, J., Wu, L., Leone, G., Rowan, S., Cepko, C.L., Zhu, X., Craft, C.M., Dyer, M.A. Nat. Genet. (2004) [Pubmed]
  10. A natural allele of Nxf1 suppresses retrovirus insertional mutations. Floyd, J.A., Gold, D.A., Concepcion, D., Poon, T.H., Wang, X., Keithley, E., Chen, D., Ward, E.J., Chinn, S.B., Friedman, R.A., Yu, H.T., Moriwaki, K., Shiroishi, T., Hamilton, B.A. Nat. Genet. (2003) [Pubmed]
  11. Genome-wide retroviral insertional tagging of genes involved in cancer in Cdkn2a-deficient mice. Lund, A.H., Turner, G., Trubetskoy, A., Verhoeven, E., Wientjens, E., Hulsman, D., Russell, R., DePinho, R.A., Lenz, J., van Lohuizen, M. Nat. Genet. (2002) [Pubmed]
  12. Successful ex vivo gene therapy directed to liver in a patient with familial hypercholesterolaemia. Grossman, M., Raper, S.E., Kozarsky, K., Stein, E.A., Engelhardt, J.F., Muller, D., Lupien, P.J., Wilson, J.M. Nat. Genet. (1994) [Pubmed]
  13. Dominant negative MYC blocks transformation by ABL oncogenes. Sawyers, C.L., Callahan, W., Witte, O.N. Cell (1992) [Pubmed]
  14. Polypeptide maps of cells infected with murine type C leukemia or sarcoma oncovirus. Strand, M., August, J.T. Cell (1978) [Pubmed]
  15. v-erbA oncogene activation entails the loss of hormone-dependent regulator activity of c-erbA. Zenke, M., Muñoz, A., Sap, J., Vennström, B., Beug, H. Cell (1990) [Pubmed]
  16. fgr proto-oncogene mRNA induced in B lymphocytes by Epstein-Barr virus infection. Cheah, M.S., Ley, T.J., Tronick, S.R., Robbins, K.C. Nature (1986) [Pubmed]
  17. Induction of a carcinogenic oncornavirus in C57BL/6 mouse embryo cells by 5-iododeoxyuridine. Lazar, A., Schlesinger, M., Horowitz, A.T., Heller, E. Nature (1975) [Pubmed]
  18. Inhibition of retroviral protease activity by an aspartyl proteinase inhibitor. Katoh, I., Yasunaga, T., Ikawa, Y., Yoshinaka, Y. Nature (1987) [Pubmed]
  19. Co-infection by lactic dehydrogenase virus and C-type retrovirus elicits neurological disease. Pease, L.R., Murphy, W.H. Nature (1980) [Pubmed]
  20. Nucleotide sequence of avian retroviral oncogene v-mil: homologue of murine retroviral oncogene v-raf. Sutrave, P., Bonner, T.I., Rapp, U.R., Jansen, H.W., Patschinsky, T., Bister, K. Nature (1984) [Pubmed]
  21. Loss of intervening sequences in genomic mouse alpha-globin DNA inserted in an infectious retrovirus vector. Shimotohno, K., Temin, H.M. Nature (1982) [Pubmed]
  22. Expression of human adenosine deaminase in murine haematopoietic progenitor cells following retroviral transfer. Belmont, J.W., Henkel-Tigges, J., Chang, S.M., Wager-Smith, K., Kellems, R.E., Dick, J.E., Magli, M.C., Phillips, R.A., Bernstein, A., Caskey, C.T. Nature (1986) [Pubmed]
  23. A new class of endogenous human retroviral genomes. Callahan, R., Chiu, I.M., Wong, J.F., Tronick, S.R., Roe, B.A., Aaronson, S.A., Schlom, J. Science (1985) [Pubmed]
  24. Activation of mouse genes in transformed cells. Scott, M.R., Westphal, K.H., Rigby, P.W. Cell (1983) [Pubmed]
  25. AKR leukemogenesis: identification and biological significance of thymic lymphoma receptors for AKR retroviruses. McGrath, M.S., Weissman, I.L. Cell (1979) [Pubmed]
  26. The molecular biology of platelet-derived growth factor. Stiles, C.D. Cell (1983) [Pubmed]
  27. Absence of significant RNA-dependent DNA polymerase activity in lymphocytes from patients with Kawasaki syndrome. Melish, M.E., Marchette, N.J., Kaplan, J.C., Kihara, S., Ching, D., Ho, D.D. Nature (1989) [Pubmed]
  28. Jun dimerization protein 2 (JDP2), a member of the AP-1 family of transcription factor, mediates osteoclast differentiation induced by RANKL. Kawaida, R., Ohtsuka, T., Okutsu, J., Takahashi, T., Kadono, Y., Oda, H., Hikita, A., Nakamura, K., Tanaka, S., Furukawa, H. J. Exp. Med. (2003) [Pubmed]
  29. Expression of the normal human sis/PDGF-2 coding sequence induces cellular transformation. Gazit, A., Igarashi, H., Chiu, I.M., Srinivasan, A., Yaniv, A., Tronick, S.R., Robbins, K.C., Aaronson, S.A. Cell (1984) [Pubmed]
  30. LYAR, a novel nucleolar protein with zinc finger DNA-binding motifs, is involved in cell growth regulation. Su, L., Hershberger, R.J., Weissman, I.L. Genes Dev. (1993) [Pubmed]
  31. Transforming growth factor (TGF)-beta1-producing regulatory T cells induce Smad-mediated interleukin 10 secretion that facilitates coordinated immunoregulatory activity and amelioration of TGF-beta1-mediated fibrosis. Kitani, A., Fuss, I., Nakamura, K., Kumaki, F., Usui, T., Strober, W. J. Exp. Med. (2003) [Pubmed]
  32. The in vitro behavior of hemopoietic cells transformed by polyoma middle T antigen parallels that of primary human myeloid leukemic cells. Metcalf, D., Roberts, T.M., Cherington, V., Dunn, A.R. EMBO J. (1987) [Pubmed]
  33. Erythropoietin-induced erythroid differentiation of the human erythroleukemia cell line TF-1 correlates with impaired STAT5 activation. Chrétien, S., Varlet, P., Verdier, F., Gobert, S., Cartron, J.P., Gisselbrecht, S., Mayeux, P., Lacombe, C. EMBO J. (1996) [Pubmed]
  34. Different H-2 subregions influence immunization against retrovirus and immunosuppression. Morrison, R.P., Earl, P.L., Nishio, J., Lodmell, D.L., Moss, B., Chesebro, B. Nature (1987) [Pubmed]
  35. A novel mechanism of retrovirus inactivation in human serum mediated by anti-alpha-galactosyl natural antibody. Rother, R.P., Fodor, W.L., Springhorn, J.P., Birks, C.W., Setter, E., Sandrin, M.S., Squinto, S.P., Rollins, S.A. J. Exp. Med. (1995) [Pubmed]
  36. Prevention of adoptively transferred diabetes in nonobese diabetic mice with IL-10-transduced islet-specific Th1 lymphocytes. A gene therapy model for autoimmune diabetes. Moritani, M., Yoshimoto, K., Ii, S., Kondo, M., Iwahana, H., Yamaoka, T., Sano, T., Nakano, N., Kikutani, H., Itakura, M. J. Clin. Invest. (1996) [Pubmed]
  37. Expression of pig endogenous retrovirus by primary porcine endothelial cells and infection of human cells. Martin, U., Kiessig, V., Blusch, J.H., Haverich, A., von der Helm, K., Herden, T., Steinhoff, G. Lancet (1998) [Pubmed]
  38. Overcoming interference to retroviral superinfection results in amplified expression and transmission of cloned genes. Bestwick, R.K., Kozak, S.L., Kabat, D. Proc. Natl. Acad. Sci. U.S.A. (1988) [Pubmed]
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