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MeSH Review

Systole

 
 
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Disease relevance of Systole

 

High impact information on Systole

 

Chemical compound and disease context of Systole

 

Biological context of Systole

 

Anatomical context of Systole

  • The velocity of circumferential fiber shortening and the percent change in the minor axis of the left ventricle during systole improved modestly (p less than 0.05) above baseline in the dobutamine group after 14 weeks of treatment and above the corresponding control values (p less than 0.05) after 22 weeks [21].
  • Because the titin spring is extended during diastolic stretch, it will recoil elastically during systole and potentially may influence the overall shortening behavior of cardiac muscle [22].
  • The effects on systolic time intervals in healthy subjects and patients (n = 6) with coronary artery disease were evaluated in relation to varying timolol dose schedules and plasma concentrations [23].
  • RESULTS: Obese patients presented diastolic function impairment, hyperkinetic systole, and greater aortic root and left atrium compared with normal subjects [24].
  • The origin and course of the myocyte to capillary collagen struts could account for capillary patency during systole in the presence of high ventricular wall pressures [25].
 

Associations of Systole with chemical compounds

 

Gene context of Systole

  • LV wall thickness during systole and % fractional shortening were diminished by 8-10% in Cx43-deficient v wild-type mice [31].
  • The titin-isoform shift may be beneficial for myocardial diastolic function, but could impair the contractile performance in systole [32].
  • LV mass, maximal LV wall thickness, and myocardial fractional thickening during systole were measured at cine MR imaging in 24 subjects (11 male, 13 female; mean age, 42 years; age range, 17-68 years) with the Asp175Asn mutation in TPM1 and in 17 healthy volunteers (eight men, nine women; mean age, 38 years; age range, 23-60 years) [33].
  • The fraction of ventricular filling due to atrial systole, the atrial filling fraction, was also reduced in CR (.21 +/- .04) compared to AL (.36 +/- .02; p = .007) [34].
  • A major factor responsible for the amount of calcium available during systole is loading of SR by SERCA [35].
 

Analytical, diagnostic and therapeutic context of Systole

References

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