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MeSH Review

Mice, Inbred C3H

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Disease relevance of Mice, Inbred C3H


Psychiatry related information on Mice, Inbred C3H


High impact information on Mice, Inbred C3H

  • Treatment of immune-competent C3H mice bearing tumors established from ras-transformed C3H-10T1/2 cells also resulted in tumor regression, although a series of injections were required [9].
  • In crosses of NOD mice with control C3H mice, the development of diabetes was dependent on homozygosity for the NOD mouse's unique major histocompatibility region [10].
  • C3H mice, in contrast, were selectively unresponsive to the MBP protein and injection of MBP:79-87 peptide induced a low avidity repertoire that could be stimulated only by the peptide, not by the protein [11].
  • To investigate whether IL-10 also subserves the function of a tolerizing agent in vivo ears of BALB/c or C3H mice were injected intradermally with 1-2 micrograms of recombinant mouse (rm)IL-10 8 h before epicutaneous application of 3% trinitrochlorobenzene (TNCB; a contact allergen) [12].
  • Inducibility of class II major histocompatibility complex antigens by interferon gamma is associated with reduced tumorigenicity in C3H mouse fibroblasts transformed by v-Ki-ras [13].

Chemical compound and disease context of Mice, Inbred C3H

  • The effect of cyclophosphamide (Cp) on the glycolytic rate of radiation-induced fibrosarcomas (RIF-1) was measured in vivo in C3H mice by following the production of [3-(13)C]lactate after tail vein infusion of labeled [1-(13)C]glucose [14].
  • Five continuous mouse mammary tumor cell lines and 12 clonal derivatives have been established from tumors arising in BALB/c or C3H mice either spontaneously or in response to viral (mammary tumor virus), hormonal (17 beta-estradiol), or chemical [7,12-dimethylbenz(alpha)anthracene] stimuli in vivo [15].
  • We have recently developed a model of primary melanoma in C3H mice induced by ethanol and UV light [16].
  • We have in this work examined the radiosensitizing potential of one such inhibitor, nicotinamide, on tumor tissue by using transplanted C3H mouse mammary adenocarcinomas and on normal tissue in a tail-stunting experiment using BALB/cA mice [17].
  • The interaction between hyperthermia and cis-diamminedichloroplatinum(II) (c-DDP) given in various schedules as an adjuvant to radiation treatment was investigated in a C3H mouse mammary carcinoma in vivo [18].

Biological context of Mice, Inbred C3H


Anatomical context of Mice, Inbred C3H


Associations of Mice, Inbred C3H with chemical compounds

  • In a study on the long-term effects of dietary diethylstilbestrol or 17 beta-estradiol on C3H mice, estrogens induced a proliferation of osseous trabeculae and increased the incidence and hastened the development of osteofibrotic areas in the sterna [29].
  • Treatment of C3H mice bearing 500-750-mg subcutaneous tumors with nicotinamide (1.0 mg/g intraperitoneally) 1 hour prior to irradiation resulted in an enhancement ratio of 1.3 (+/- 0.1) [30].
  • The hypoxic cell sensitizer misonidazole (Ro 07-0582),1-(2-nitro-1-imidazolyl)-3-methoxy-2-propanol, significantly enhanced the local control of the weakly immunogenic C3H mouse mammary carcinoma MDAH-MCa-4 (8-mm diameter) by single doses of radiation [31].
  • Levamisole was added to regimens involving asparaginase therapy of 6C3HED-bearing C3H mice and chemoimmunotherapy of BALB/c mice bearing P1798 with methotrexate and iodoacetamide-modified P1798 cells [32].
  • However, when maintained on an atherogenic diet high in fat and cholesterol, the HDL isolated from B6 mice lose the capacity to protect, whereas HDL from C3H mice protect equally well [33].

Gene context of Mice, Inbred C3H

  • Injection of mildly oxidized LDL (but not native LDL) into BL/6 mice (but not in C3H mice) on a chow diet resulted in a 59% decrease in PON activity (P < 0.01) and a 3.6-fold increase in apoJ levels (P < 0.01) [34].
  • The Hfe -/- mice also demonstrated strain-dependent differences in transferrin saturation, with the highest values in AKR mice and the lowest values in C3H mice [35].
  • These results suggest that UV-induced C3H mouse tumors display mutations preferentially in the N-ras oncogene [36].
  • IL-12 depletion of C3H mice also suppressed OVA-specific serum IgG2a levels and increased both serum OVA-specific IgG1 and IgE levels [37].
  • In conventional BALB/c or C3H mice, B7-2 functions as the dominant costimulatory molecule in the initiation of early T cell activation following L. major infection, leading to IL-4 or IFN-gamma production, respectively [38].

Analytical, diagnostic and therapeutic context of Mice, Inbred C3H

  • Active immunization with recombinant P21 did not protect C3H mice from tick-borne B. burgdorferi infection, and passive transfer of P21 antiserum to infected mice did not alter the course of disease [39].
  • In this paper we report the production of collagenase and elastase activities by the primary tumor cultures and three types of cloned C3H mouse mammary adenocarcinoma cell cultures [40].
  • Efficacy of antitumor chemotherapy in C3H mice enhanced by the antiangiogenesis steroid, cortisone acetate [41].
  • Strikingly, anti-IL-12 mAb (1 mg/mouse) treatment resulted in threefold increases in airway reactivity in OVA-challenged resistant C3H mice, concomitant with significant increases in bronchoalveolar lavage levels of Th2 cytokines and decreases in IFN-gamma [37].
  • Using the technique of Southern blot hybridization, the H-2 genes and integrated SV40 sequences present in the genomic DNA of several of these clones have been examined and compared with both the parent line and normal liver genomic DNA from C3H mice [42].


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  3. Mechanism of antitumor activity of tumor necrosis factor alpha with hyperthermia in a tumor necrosis factor alpha-resistant tumor. Srinivasan, J.M., Fajardo, L.F., Hahn, G.M. J. Natl. Cancer Inst. (1990) [Pubmed]
  4. Effect of anti-interleukin 12 treatment on murine lyme borreliosis. Anguita, J., Persing, D.H., Rincon, M., Barthold, S.W., Fikrig, E. J. Clin. Invest. (1996) [Pubmed]
  5. Properties of a subpopulation of T cells bearing histamine receptors. Plaut, M., Lichtenstein, L.M., Henney, C.S. J. Clin. Invest. (1975) [Pubmed]
  6. Cyclophosphamide induced DNA strand breaks in mouse embryo cephalic tissue in vivo. Pillans, P.I., Ponzi, S.F., Parker, M.I. Carcinogenesis (1989) [Pubmed]
  7. Neuromedin-U is regulated by the circadian clock in the SCN of the mouse. Graham, E.S., Littlewood, P., Turnbull, Y., Mercer, J.G., Morgan, P.J., Barrett, P. Eur. J. Neurosci. (2005) [Pubmed]
  8. MAO A knockout attenuates adrenocortical response to various kinds of stress. Popova, N.K., Maslova, L.N., Morosova, E.A., Bulygina, V.V., Seif, I. Psychoneuroendocrinology (2006) [Pubmed]
  9. Reovirus therapy of tumors with activated Ras pathway. Coffey, M.C., Strong, J.E., Forsyth, P.A., Lee, P.W. Science (1998) [Pubmed]
  10. The NOD mouse: recessive diabetogenic gene in the major histocompatibility complex. Hattori, M., Buse, J.B., Jackson, R.A., Glimcher, L., Dorf, M.E., Minami, M., Makino, S., Moriwaki, K., Kuzuya, H., Imura, H. Science (1986) [Pubmed]
  11. Endogenous myelin basic protein inactivates the high avidity T cell repertoire. Targoni, O.S., Lehmann, P.V. J. Exp. Med. (1998) [Pubmed]
  12. Induction of hapten-specific tolerance by interleukin 10 in vivo. Enk, A.H., Saloga, J., Becker, D., B1P6madzadeh, M., Knop, J. J. Exp. Med. (1994) [Pubmed]
  13. Inducibility of class II major histocompatibility complex antigens by interferon gamma is associated with reduced tumorigenicity in C3H mouse fibroblasts transformed by v-Ki-ras. Bateman, W.J., Fiera, R., Matthews, N., Morris, A.G. J. Exp. Med. (1991) [Pubmed]
  14. Cyclophosphamide treatment modifies tumor oxygenation and glycolytic rates of RIF-1 tumors: 13C magnetic resonance spectroscopy, Eppendorf electrode, and redox scanning. Poptani, H., Bansal, N., Jenkins, W.T., Blessington, D., Mancuso, A., Nelson, D.S., Feldman, M., Delikatny, E.J., Chance, B., Glickson, J.D. Cancer Res. (2003) [Pubmed]
  15. Comparison of the growth properties in vitro and transplantability of continuous mouse mammary tumor cell lines and clonal derivatives. Butel, J.S., Dudley, J.P., Medina, D. Cancer Res. (1977) [Pubmed]
  16. Molecular characterization of new melanoma cell lines from C3H mice induced by ethanol plus ultraviolet radiation. Strickland, F.M., Pathak, S., Multani, A.S., Pelley, R.P., Donawho, C.K. Cancer Res. (2003) [Pubmed]
  17. Radiosensitization effects of nicotinamide on malignant and normal mouse tissue. Jonsson, G.G., Kjellén, E., Pero, R.W., Cameron, R. Cancer Res. (1985) [Pubmed]
  18. Interaction of hyperthermia and cis-diamminedichloroplatinum(II) alone or combined with radiation in a C3H mammary carcinoma in vivo. Overgaard, J., Radacic, M.M., Grau, C. Cancer Res. (1991) [Pubmed]
  19. Inhibition of tumorigenicity of the teratoma PC cell line by transfection with antisense cDNA for PC cell-derived growth factor (PCDGF, epithelin/granulin precursor). Zhang, H., Serrero, G. Proc. Natl. Acad. Sci. U.S.A. (1998) [Pubmed]
  20. Expression of recombinant glutathione S-transferase pi, Ya, or Yb1 confers resistance to alkylating agents. Puchalski, R.B., Fahl, W.E. Proc. Natl. Acad. Sci. U.S.A. (1990) [Pubmed]
  21. Effect of iodoacetate on the bone marrow immunocompetence of AKR mice. Rheins, M.S., Filppi, J.A., Moore, V.S. Cancer Res. (1975) [Pubmed]
  22. Effects of double and multiple doses of hydroxyurea on mouse duodenum and mammary tumors. Dethlefsen, L.A., Sorensen, S.P., Riley, R.M. Cancer Res. (1975) [Pubmed]
  23. Modification of sister chromatid exchanges and radiation-induced transformation in rodent cells by the tumor promoter 12-O-tetradecanoylphorbol-13-acetate and two retinoids. Miller, R.C., Geard, C.R., Osmak, R.S., Rutledge-Freeman, M., Ong, A., Mason, H., Napholz, A., Perez, N., Harisiadis, L., Borek, C. Cancer Res. (1981) [Pubmed]
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  26. Molecular and biological interaction between major histocompatibility complex class I antigens and luteinizing hormone receptors or beta-adrenergic receptors triggers cellular response in mice. Solano, A.R., Cremaschi, G., Sánchez, M.L., Borda, E., Sterin-Borda, L., Podestá, E.J. Proc. Natl. Acad. Sci. U.S.A. (1988) [Pubmed]
  27. Novel muscle-specific enhancer sequences upstream of the cardiac actin gene. Biben, C., Kirschbaum, B.J., Garner, I., Buckingham, M. Mol. Cell. Biol. (1994) [Pubmed]
  28. Role of IL-4 and IFN-gamma in modulation of immunity to Borrelia burgdorferi in mice. Keane-Myers, A., Nickell, S.P. J. Immunol. (1995) [Pubmed]
  29. Osseous changes and osteosacomas in mice continuously fed diets containing diethylstilbestrol or 17 beta-estradiol. Highman, B., Roth, S.I., Greenman, D.L. J. Natl. Cancer Inst. (1981) [Pubmed]
  30. Effect of nicotinamide on the microregional heterogeneity of oxygen delivery within a murine tumor. Chaplin, D.J., Horsman, M.R., Trotter, M.J. J. Natl. Cancer Inst. (1990) [Pubmed]
  31. Modification of radiation responses of murine tumors by misonidazole (Ro 07-0582), host immune capability, and Corynebacterium parvum. Stone, H.B., Milas, L. J. Natl. Cancer Inst. (1978) [Pubmed]
  32. Effects of levamisole on normal and malignant murine lymphocytes. Gordon, W.C., Prager, M.D. J. Natl. Cancer Inst. (1978) [Pubmed]
  33. Genetic-dietary regulation of serum paraoxonase expression and its role in atherogenesis in a mouse model. Shih, D.M., Gu, L., Hama, S., Xia, Y.R., Navab, M., Fogelman, A.M., Lusis, A.J. J. Clin. Invest. (1996) [Pubmed]
  34. Mildly oxidized LDL induces an increased apolipoprotein J/paraoxonase ratio. Navab, M., Hama-Levy, S., Van Lenten, B.J., Fonarow, G.C., Cardinez, C.J., Castellani, L.W., Brennan, M.L., Lusis, A.J., Fogelman, A.M., La Du, B.N. J. Clin. Invest. (1997) [Pubmed]
  35. Mouse strain differences determine severity of iron accumulation in Hfe knockout model of hereditary hemochromatosis. Fleming, R.E., Holden, C.C., Tomatsu, S., Waheed, A., Brunt, E.M., Britton, R.S., Bacon, B.R., Roopenian, D.C., Sly, W.S. Proc. Natl. Acad. Sci. U.S.A. (2001) [Pubmed]
  36. N-ras mutation in ultraviolet radiation-induced murine skin cancers. Pierceall, W.E., Kripke, M.L., Ananthaswamy, H.N. Cancer Res. (1992) [Pubmed]
  37. Resistance to antigen-induced airway hyperresponsiveness requires endogenous production of IL-12. Keane-Myers, A., Wysocka, M., Trinchieri, G., Wills-Karp, M. J. Immunol. (1998) [Pubmed]
  38. Expression and contribution of B7-1 (CD80) and B7-2 (CD86) in the early immune response to Leishmania major infection. Elloso, M.M., Scott, P. J. Immunol. (1999) [Pubmed]
  39. Temporal pattern of Borrelia burgdorferi p21 expression in ticks and the mammalian host. Das, S., Barthold, S.W., Giles, S.S., Montgomery, R.R., Telford, S.R., Fikrig, E. J. Clin. Invest. (1997) [Pubmed]
  40. Collagenase and elastase production by mouse mammary adenocarcinoma primary cultures and cloned cells. Zeydel, M., Nakagawa, S., Biempica, L., Takahashi, S. Cancer Res. (1986) [Pubmed]
  41. Efficacy of antitumor chemotherapy in C3H mice enhanced by the antiangiogenesis steroid, cortisone acetate. Lee, K., Erturk, E., Mayer, R., Cockett, A.T. Cancer Res. (1987) [Pubmed]
  42. Analysis of a defect in the H-2 genes of SV40 transformed C3H fibroblasts that do not express H-2Kk. Rogers, M.J., Gooding, L.R., Margulies, D.H., Evans, G.A. J. Immunol. (1983) [Pubmed]
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