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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
 
 
 
 

Self-administration of intravenous amphetamine is predicted by individual differences in sucrose feeding in rats.

RATIONALE: Previous studies have shown that individual differences in oral sucrose consumption are predictive of the psychomotor and dopamine (DA) stimulant properties of amphetamine in rats. OBJECTIVES: The present experiment was designed to examine the relationship between sucrose feeding and the reinforcing properties of amphetamine using the intravenous (i.v.) drug self-administration paradigm. METHODS: Based on a median split of sucrose intake during a final 1-h feeding test session, male Wistar rats were designated as either low ( LSF) or high sucrose feeders (HSF). Acquisition of i. v.-amphetamine self-administration across ten daily 30-min sessions was then assessed. Following acquisition, i.v. self-administration of several doses of amphetamine was similarly tested across daily 30-min sessions. RESULTS: Data from this experiment revealed augmented responding in HSF compared with LSF during acquisition of amphetamine self-administration. Correspondingly, when given access to different doses of amphetamine, responding was greater in HSF than in LSF across several doses (3 microg and 10 microg per infusion). CONCLUSIONS: These data support the notion that individual differences in oral sucrose consumption are predictive of the reinforcing properties of psychostimulant drugs.[1]

References

  1. Self-administration of intravenous amphetamine is predicted by individual differences in sucrose feeding in rats. DeSousa, N.J., Bush, D.E., Vaccarino, F.J. Psychopharmacology (Berl.) (2000) [Pubmed]
 
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