- The Huntington's disease protein interacts with p53 and CREB-binding protein and represses transcription. Steffan, J.S., Kazantsev, A., Spasic-Boskovic, O., Greenwald, M., Zhu, Y.Z., Gohler, H., Wanker, E.E., Bates, G.P., Housman, D.E., Thompson, L.M. Proc. Natl. Acad. Sci. U.S.A. (2000)