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Auger, A.P. et al.

Auger, Tetel, McCarthy,

Steroid receptor coactivator-1 (SRC-1) mediates the development of sex-specific brain morphology and behavior.

Steroid hormone action during brain development exerts profound effects on reproductive physiology and behavior that last into adulthood. A variety of in vitro studies indicate that steroid receptors require nuclear receptor coactivators for efficient transcriptional activity. To determine the functional significance of the nuclear receptor coactivator SRC-1 in developing brain, we investigated the consequence of reducing SRC-1 protein during sexual differentiation of the brain. We report that reducing SRC-1 protein interferes with the defeminizing actions of estrogen in neonatal rat brain. Our data indicate that SRC-1 protein expression is critically involved in the hormone-dependent development of normal male reproductive behavior and brain morphology.[1]

References

Steroid receptor coactivator-1 (SRC-1) mediates the development of sex-specific brain morphology and behavior. Auger, A.P., Tetel, M.J., McCarthy, M.M. Proc. Natl. Acad. Sci. U.S.A. (2000) [Pubmed]

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