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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
 
 
 
 

Detection of human alpha-defensin-1, an antimicrobial peptide, in the fluid of jaw cysts.

OBJECTIVE: The purpose of this study was to isolate and to identify an antimicrobial peptide, human alpha-defensin-1 ( HNP-1) in jaw cyst fluid. STUDY DESIGN: We collected jaw cyst fluid from 22 patients with various jaw cysts and analyzed the peptide components of them by reversed-phase high-performance liquid chromatography (HPLC). HNP-1 in the jaw cyst fluid was identified by the amino acid sequence and the molecular weight. The concentration of HNP-1 in the fluid of various jaw cysts was quantified by HPLC. RESULTS: HNP-1 in the jaw cyst fluid was isolated, purified, and identified. The concentrations of HNP-1 in the jaw cyst fluid ranged from 27.0 to 3725.4 microg/mL. CONCLUSION: HNP-1 was detected in the fluid of various types of jaw cysts.[1]

References

  1. Detection of human alpha-defensin-1, an antimicrobial peptide, in the fluid of jaw cysts. Mizukawa, N., Sugiyama, K., Ueno, T., Mishima, K., Takagi, S., Sugahara, T. Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics. (2000) [Pubmed]
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