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Lemstra, A.W. et al.

Lemstra, van Meegen, Vreyling, Meijerink, Jansen, Bulk, Baas, van Gool,

14-3-3 testing in diagnosing Creutzfeldt-Jakob disease: a prospective study in 112 patients.

OBJECTIVE: To study the sensitivity and specificity of 14-3-3 testing in a prospective series of patients suspected of having Creutzfeldt-Jakob disease (CJD). BACKGROUND: The 14-3-3 protein immunoassay on CSF has favorable test characteristics as a premortem diagnostic tool in CJD. However, the 14-3-3 protein is a normal cellular protein expressed in various tissues, and its presence in CSF reflects extensive destruction of brain tissue as in CJD, but also in ischemic stroke and meningoencephalitis. METHODS: 14-3-3 was tested in the CSF of a prospective series of 110 consecutive patients suspected of having CJD. RESULTS: The sensitivity was 97% and the specificity was 87% in this series. False-positive results were mainly caused by stroke and meningoencephalitis. CONCLUSION: The 14-3-3 protein is a highly sensitive and specific marker for CJD when used in the appropriate clinical context.[1]

References

14-3-3 testing in diagnosing Creutzfeldt-Jakob disease: a prospective study in 112 patients. Lemstra, A.W., van Meegen, M.T., Vreyling, J.P., Meijerink, P.H., Jansen, G.H., Bulk, S., Baas, F., van Gool, W.A. Neurology (2000) [Pubmed]

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