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Blockage of ovulation in rats by inhibitory analogs of luteinizing hormones-releasing hormone.

An antagonist of luteinizing hormone-releasing hormone (LH-RH). [D-Phe2-Phe3-D-Phe6]-LH-RH (Phe, phenylalanine), suppressed luteinizing hormone (LH) and follicle-stimulating hormone (FSH) release in male rats in response to LH-RH for at least 4 hours. Three subcutaneous injection of 1 milligram of this antagonist into rats during proestrus completely suppressed ovulation, while a single injection of 1.5 milligrams per rat inhibited 95.3 percent of the preovulatory surge of LH, 84.2 percent of the FSH surge, and suppressed ovulation by 86.4 percent.[1]

References

  1. Blockage of ovulation in rats by inhibitory analogs of luteinizing hormones-releasing hormone. De la Cruz, A., Coy, D.H., Vilchez-Martinez, J.A., Arimura, A., Schelly, A.V. Science (1976) [Pubmed]
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