- Activation of the murine EP3 receptor for PGE2 inhibits cAMP production and promotes platelet aggregation. Fabre, J.E., Nguyen, M., Athirakul, K., Coggins, K., McNeish, J.D., Austin, S., Parise, L.K., FitzGerald, G.A., Coffman, T.M., Koller, B.H. J. Clin. Invest. (2001)