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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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McSorley, S.J. et al.

McSorley, Asch, Costalonga, Reinhardt, Jenkins,

Tracking salmonella-specific CD4 T cells in vivo reveals a local mucosal response to a disseminated infection.

A novel adoptive transfer system was used to track the fate of naive Salmonella-specific CD4 T cells in vivo. These cells showed signs of activation in the Peyer's patches as early as 3 hr after oral infection. The activated CD4 T cells then produced IL-2 and proliferated in the T cell areas of these tissues before migrating into the B cell-rich follicles. In contrast, Salmonella-specific CD4 T cells were not activated in the spleen and very few of these cells migrated to the liver, despite the presence of bacteria in both organs. These results show that the T cell response to pathogenic Salmonella infection is localized to the gut-associated lymphoid tissue and does not extend efficiently to the major sites of late infection.[1]

References

Tracking salmonella-specific CD4 T cells in vivo reveals a local mucosal response to a disseminated infection. McSorley, S.J., Asch, S., Costalonga, M., Reinhardt, R.L., Jenkins, M.K. Immunity (2002) [Pubmed]

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