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Neurotrophin-evoked depolarization requires the sodium channel Na(V)1.9.
Brain-derived neurotrophic factor ( BDNF) and other neurotrophins are essential for normal brain function. Many types of neurons in the central nervous system are excited by BDNF or neurotrophin-4/5, an action that has recently been implicated in synaptic plasticity. The mechanisms involved in this transmitter-like action of neurotrophins remains unclear. Here, by screening candidate genes with an antisense messenger RNA expression approach and by co-expressing the receptor tyrosine kinase TrkB and various sodium channels, we demonstrate that the tetrodotoxin-insensitive sodium channel Na(V)1.9 underlies the neurotrophin-evoked excitation. These results establish the molecular basis of neurotrophin-evoked depolarization and reveal a mechanism of ligand-mediated sodium channel activation.[1]References
- Neurotrophin-evoked depolarization requires the sodium channel Na(V)1.9. Blum, R., Kafitz, K.W., Konnerth, A. Nature (2002) [Pubmed]
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