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Suppression of spectinomycin resistance in a mutant of Escherichia coli K-12.
A mutant of Escherichia coli has been isolated which exhibits partial suppression of spectinomycin resistance. The site of mutation is in the streptomycin ( strA) region and is closely linked to the spcA gene. However, this gene, which we propose to call mod, is phenotypically distinguishable from both the neomycin-kanamycin (nek) and the ribosomal ambiguity gene (ram). The relative gene order is mod spcA strA. In a cell-free protein synthesizing system, altered ribosomes appear to be responsible for the suppression of spectinomycin resistance caused by mod.[1]References
- Suppression of spectinomycin resistance in a mutant of Escherichia coli K-12. Berg, P.E., Kang, S.S. J. Bacteriol. (1975) [Pubmed]
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