- Oxidized phospholipids in oxidized low-density lipoprotein down-regulate thrombomodulin transcription in vascular endothelial cells through a decrease in the binding of RARbeta-RXRalpha heterodimers and Sp1 and Sp3 to their binding sequences in the TM promoter. Ishii, H., Tezuka, T., Ishikawa, H., Takada, K., Oida, K., Horie, S. Blood (2003)