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The molecular mystery of neuronal migration: FAK and Cdk5.
The basic building blocks of a cell are its cytoskeletal proteins, the orderly but dynamic organization of which is essential. How signalling molecules regulate the cytoskeleton in the developing nervous system is still largely unknown. A recent breakthrough sheds light on a pathway involving Cdk5 (cyclin-dependent kinase 5) and FAK (focal adhesion kinase), demonstrating their role in regulating microtubule structure and thus nuclear positioning in radially migrating cortical neurones.[1]References
- The molecular mystery of neuronal migration: FAK and Cdk5. Nikolic, M. Trends Cell Biol. (2004) [Pubmed]
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