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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
 
 
 
 

Hyperhomocysteinaemia in treated patients with Huntington's disease homocysteine in HD.

Significantly increased plasma total homocysteine levels (t-Hcys) appeared in treated Huntington disease (HD) patients compared to controls and untreated HD subjects. Because the protein Huntingtin interacts with the homocysteine metabolism modulating enzyme cystathionine beta-synthase, we hypothesize that homocysteine promotes neurodegeneration in HD.[1]

References

  1. Hyperhomocysteinaemia in treated patients with Huntington's disease homocysteine in HD. Andrich, J., Saft, C., Arz, A., Schneider, B., Agelink, M.W., Kraus, P.H., Kuhn, W., Müller, T. Mov. Disord. (2004) [Pubmed]
 
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