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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

PRDI-BF1 recruits the histone H3 methyltransferase G9a in transcriptional silencing.

PRDI-BF1, the human ortholog of mouse Blimp-1, is a DNA-binding protein involved in postinduction repression of interferon-beta gene transcription in response to viral infection. PRDI-BF1 also has an essential function in driving terminal differentiation of B lymphocytes and therein silences multiple genes. Here we show PRDI-BF1 assembles silent chromatin over the interferon-beta promoter in the osteosarcoma cell line U2OS through recruitment of the histone H3 lysine methyltransferase G9a. G9a is recruited only when in a complex with PRDI-BF1. G9a catalytic activity is required for the accumulation of methylated histone H3 and transcriptional silencing mediated by PRDI-BF1 in vivo. This establishes a mechanism for the recruitment of G9a, the main mammalian euchromatic methyltransferase, and defines nonembryonic targets of G9a.[1]


  1. PRDI-BF1 recruits the histone H3 methyltransferase G9a in transcriptional silencing. Gyory, I., Wu, J., Fejér, G., Seto, E., Wright, K.L. Nat. Immunol. (2004) [Pubmed]
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