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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Rosenmann, H. et al.

Rosenmann, Meiner, Dresner-Pollak, Kahana, Aladjem, Grenader, Wertman, Abramsky,

Lack of association of interleukin-1beta polymorphism with Alzheimer's disease in the Jewish population.

A growing body of evidence suggests that Alzheimer's disease (AD) is associated with local inflammation processes, including the activation of inflammatory cytokines. We performed a case-control association study between sporadic AD patients and the exon 5 position +3953 polymorphism in the potent pro-inflammatory cytokine, interleukin-1beta (IL-1B). Recent association studies of this locus with AD revealed conflicting results, suggesting that the association - if it exists - is not universal but rather population specific. In our study no association was detected with AD: neither as a risk factor nor as a modifier gene affecting the age at onset and disease progression. These findings show no evidence for an association between the IL-1B +3953 polymorphism and AD in the Jewish population.[1]

References

Lack of association of interleukin-1beta polymorphism with Alzheimer's disease in the Jewish population. Rosenmann, H., Meiner, Z., Dresner-Pollak, R., Kahana, E., Aladjem, Z., Grenader, T., Wertman, E., Abramsky, O. Neurosci. Lett. (2004) [Pubmed]

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