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Huntington's disease: new paths to pathogenesis.
Huntington's disease is a progressive autosomal dominant neurodegenerative disorder caused by expansion of a CAG repeat coding for polyglutamine in the huntingtin protein. A recent report suggests a new mechanism involving altered interactions with a protein involved in axonal transport, leading to loss of neurotrophic factor transport. This suggests an intriguing convergence to previously described pathways implicating neurotrophin transcription in HD pathogenesis.[1]References
- Huntington's disease: new paths to pathogenesis. Ross, C.A. Cell (2004) [Pubmed]
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