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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
 
 
 
 

Requirement of matrix metalloproteinase-9 for the transformation of human mammary epithelial cells by Stat3-C.

Persistently activated Stat3 is found in many different cancers, including approximately 60% of breast tumors. Here, we demonstrate that a constitutively activated Stat3 transforms immortalized human mammary epithelial cells and that this oncogenic event requires the activity of matrix metalloproteinase-9 (MMP-9). By immunohistochemical analysis, we observe a positive correlation between strong MMP-9 expression and tyrosine phosphorylated Stat3 in primary breast cancer specimens. These results demonstrate a relationship between activated Stat3 and MMP-9 in breast oncogenesis.[1]

References

  1. Requirement of matrix metalloproteinase-9 for the transformation of human mammary epithelial cells by Stat3-C. Dechow, T.N., Pedranzini, L., Leitch, A., Leslie, K., Gerald, W.L., Linkov, I., Bromberg, J.F. Proc. Natl. Acad. Sci. U.S.A. (2004) [Pubmed]
 
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