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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
 
 
 
 

Elevated plasma levels of fibrin degradation products by granulocyte-derived elastase in patients with deep vein thrombosis.

Plasma levels of granulocyte-derived elastase (GE- XDP), D-dimer and soluble fibrin (SF) were examined in 53 patients with deep vein thrombosis (DVT) and in 100 healthy volunteers. The mean plasma level of D-dimer was 0.92+/-0.81 microg/ml (+/-S.D.) in healthy volunteers and the mean+2 S.D. value (cutoff value for DVT) was 2.53 microg/ml, which was higher than that used in Europe and North America. Plasma levels of GE- XDP, D-dimer and SF were significantly higher in patients with DVT than in healthy volunteers, and diminished after 1 week of treatment with heparin, urokinase or tissue type plasminogen activator, though were still higher than those of the control subjects. The sensitivity of GE- XDP, D-dimer and SF for DVT was 81.1%, 75.5% and 79.2%, respectively. GE- XDP levels correlated with those of D-dimer and SF. Our results indicate that GE- XDP is a potentially useful marker for the diagnosis of DVT, suggesting that granulocytes are activated in patients with DVT. In our system, the cutoff value of D-dimer for the diagnosis of DVT is higher than in western countries, probably due to the use of different analytical assays.[1]

References

  1. Elevated plasma levels of fibrin degradation products by granulocyte-derived elastase in patients with deep vein thrombosis. Kamikura, Y., Wada, H., Nobori, T., Matsumoto, T., Shiku, H., Ishikura, K., Yamada, N., Nakano, T., Kazahaya, Y., Sawai, T., Matsuda, M. Thromb. Res. (2005) [Pubmed]
 
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