- Cotreatment with suberanoylanilide hydroxamic acid and 17-allylamino 17-demethoxygeldanamycin synergistically induces apoptosis in Bcr-Abl+ Cells sensitive and resistant to STI571 (imatinib mesylate) in association with down-regulation of Bcr-Abl, abrogation of signal transducer and activator of transcription 5 activity, and Bax conformational change. Rahmani, M., Reese, E., Dai, Y., Bauer, C., Kramer, L.B., Huang, M., Jove, R., Dent, P., Grant, S. Mol. Pharmacol. (2005)