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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
 
 
 
 

Focal adhesion kinase: in command and control of cell motility.

A central question in cell biology is how membrane-spanning receptors transmit extracellular signals inside cells to modulate cell adhesion and motility. Focal adhesion kinase ( FAK) is a crucial signalling component that is activated by numerous stimuli and functions as a biosensor or integrator to control cell motility. Through multifaceted and diverse molecular connections, FAK can influence the cytoskeleton, structures of cell adhesion sites and membrane protrusions to regulate cell movement.[1]

References

  1. Focal adhesion kinase: in command and control of cell motility. Mitra, S.K., Hanson, D.A., Schlaepfer, D.D. Nat. Rev. Mol. Cell Biol. (2005) [Pubmed]
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