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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Effect of hyperprolinemia on acetylcholinesterase and butyrylcholinesterase activities in rat.

We observed here that acute proline (Pro) administration provoked a decrease (32%) of acetylcholinesterase (AChE) activity in cerebral cortex and an increase (22%) of butyrylcholinesterase (BuChE) activity in the serum of 29-day-old rats. In contrast, chronic administration of Pro did not alter AChE or BuChE activities. Furthermore, pretreatment of rats with vitamins E and C combined or alone, N(omega)-nitro-L-arginine methyl ester or melatonin prevented the reduction of AChE activity caused by acute Pro administration, suggesting the participation of oxidative stress in such effects.[1]

References

  1. Effect of hyperprolinemia on acetylcholinesterase and butyrylcholinesterase activities in rat. Delwing, D., Chiarani, F., Wannmacher, C.M., Wajner, M., Wyse, A.T. Amino Acids (2005) [Pubmed]
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