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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
 
 

HIV-dementia, Tat-induced oxidative stress, and antioxidant therapeutic considerations.

Oxidative stress is thought to play a role in the onset of dementia. HIV-dementia has recently been demonstrated to be associated with oxidative stress as indexed by increased protein and lipid peroxidation in the brain and cerebrospinal fluid compared to HIV non-demented patients. The HIV protein Tat induces neurotoxicity, and, more recently, Tat was found to induce oxidative stress directly and indirectly. The role of Tat in HIV-dementia and possible therapeutic strategies involving endogenous and exogenous antioxidants are discussed.[1]

References

  1. HIV-dementia, Tat-induced oxidative stress, and antioxidant therapeutic considerations. Pocernich, C.B., Sultana, R., Mohmmad-Abdul, H., Nath, A., Butterfield, D.A. Brain Res. Brain Res. Rev. (2005) [Pubmed]
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