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Human serum transferrin cobalt complex: stability and cellular uptake of cobalt.
Transferrin (Tf) receptor expression is up-regulated on tumour cells. The human serum iron transport protein transferrin ( Tf) can bind to many metals including gallium and cobalt. Cobalt has a positron-emitting isotope with a half-life of 18 h and would thus be a useful isotope for imaging purposes. This study has examined the stability of the Co- Tf in the presence of serum and albumin and the uptake of radioactive Co from Co- Tf by tumour cells. Dialysis of 57Co- Tf with serum or with apo- Tf resulted in loss of most 57Co from the complex. The time course of Co uptake from cells incubated with Co- Tf showed an initial rapid association with cells, then a slower rate of accumulation, that is, a similar uptake profile to that of iron. Competition and displacement experiments showed that uptake specifically occurred by interaction with Tf receptors.[1]References
- Human serum transferrin cobalt complex: stability and cellular uptake of cobalt. Smith, T.A. Bioorg. Med. Chem. (2005) [Pubmed]
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