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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Won Park, K. et al.

Identification of new netrin family members in zebrafish: developmental expression of netrin 2 and netrin 4.

Netrin 1 is a diffusible factor that attracts commissural axons to the floor plate of the spinal cord. Recent evidence indicates that Netrin 1 is widely expressed and functions in the development of multiple organ systems. In mammals, there are three genes encoding Netrins, whereas in zebrafish, only the Netrin 1 orthologs netrin 1a and netrin 1b have been identified. Here, we have cloned two new zebrafish Netrins, netrin 2 and netrin 4, and present a comparative sequence and expression analysis. Despite significant sequence similarity with netrin 1a/netrin 1b, netrin 2 displays a unique expression pattern. Netrin 2 transcript is first detected in the notochord and in developing somites at early somitogenesis. By late somitogenesis, netrin 2 is expressed in the fourth rhombomere and is subsequently expressed in the hindbrain and otic vesicles. In contrast, netrin 4 is detected only at very low levels during early development. The nonoverlapping expression patterns of these four Netrins suggest that they may play unique roles in zebrafish development.[1]

References

Identification of new netrin family members in zebrafish: developmental expression of netrin 2 and netrin 4. Won Park, K., Urness, L.D., Senchuk, M.M., Colvin, C.J., Wythe, J.D., Chien, C.B., Li, D.Y. Dev. Dyn. (2005) [Pubmed]

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