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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Appendino, G. et al.

Appendino, Prosperini, Valdivia, Ballero, Colombano, Billington, Genazzani, Sterner,

SERCA-inhibiting activity of C-19 terpenolides from Thapsia garganica and their possible biogenesis.

An investigation of Thapsia garganica afforded a series of tetracyclic C-19 dilactones, whose production was dependent on the time and location of the collection. These unusual tetrahomosesquiterpenoids are presumably biosynthesized via a carbon dioxide-triggered electrophilic polyolefin cyclization. Despite the structural differences with thapsigargin, these compounds showed SERCA-inhibiting properties.[1]

References

SERCA-inhibiting activity of C-19 terpenolides from Thapsia garganica and their possible biogenesis. Appendino, G., Prosperini, S., Valdivia, C., Ballero, M., Colombano, G., Billington, R.A., Genazzani, A.A., Sterner, O. J. Nat. Prod. (2005) [Pubmed]

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