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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
 
 
 
 

Protection of macaques from vaginal SHIV challenge by an orally delivered CCR5 inhibitor.

Pre-exposure oral prophylaxis with antiviral drugs is a potential method for preventing transmission of human immunodeficiency virus type 1 (HIV-1). We show that oral delivery of CMPD167, a small molecule that binds to the CCR5 coreceptor, for 10-14 d can protect a substantial proportion of macaques from vaginal infection with a CCR5-using virus (SHIV-162P3). The macaques that became infected despite receiving CMPD167 had reduced plasma viremia levels during the earliest stages of infection.[1]

References

  1. Protection of macaques from vaginal SHIV challenge by an orally delivered CCR5 inhibitor. Veazey, R.S., Springer, M.S., Marx, P.A., Dufour, J., Klasse, P.J., Moore, J.P. Nat. Med. (2005) [Pubmed]
 
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