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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Hattori, H. et al.

Hattori, Matsuzaki, Suminoe, Koga, Tashiro, Hara,

Identification of novel genes with prognostic value in childhood leukemia using cDNA microarray and quantitative RT-PCR.

The aim of this study was to identify genes distinctively expressed or suppressed in childhood leukemia with different prognoses, using cDNA microarray and quantitative reverse transcription-polymerase chain reaction (RT-PCR). The expression levels of the selected genes by cDNA microarray were quantified in primary leukemic blasts from 44 patients (acute lymphoblastic leukemia, 28; acute myelogenous leukemia (AML), 13; transient myeloproliferative disorder, 3). The expression levels of CDKN2C, CRADD, and IGFBP-2 genes were significantly associated with the event-free survival of the patients in AML. The present results suggest that a combination of cDNA microarray and quantitative RT-PCR may be useful to identify novel genes with prognostic value in childhood AML.[1]

References

Identification of novel genes with prognostic value in childhood leukemia using cDNA microarray and quantitative RT-PCR. Hattori, H., Matsuzaki, A., Suminoe, A., Koga, Y., Tashiro, K., Hara, T. Pediatric hematology and oncology. (2006) [Pubmed]

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