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Statistical false positive or true disease pathway?

Three very recent reports provide convincing statistical evidence (P < 10(-8)), at a genome-wide level, of the association of common polymorphisms with three different common diseases: systemic lupus erythematosus ( IRF5), prostate cancer and type 1 diabetes (IFIH1 region). This adds to the trickle--soon to be a flood--of disease association results that are highly unlikely to be false positives. There are other convincing examples in the last 12 months: age-related macular degeneration ( CFH), type 1 diabetes ( IL2RA, also known as CD25) and type 2 diabetes ( TCF7L2). Given 20 years of a literature full of irreproducible results, what has changed?[1]

References

  1. Statistical false positive or true disease pathway? Todd, J.A. Nat. Genet. (2006)
 
 
 
 
 
 
 
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