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A Hopscotch-chromatin connection.

Dysregulation of the JAK-STAT pathway is implicated in human cancer and leads to a hematopoietic tumor phenotype in flies. Now, an enhancer-suppressor screen of the fly tumor model connects the JAK kinase Hopscotch pathway with chromatin-modifying proteins and heterochromatic gene silencing.[1]

References

  1. A Hopscotch-chromatin connection. Betz, A., Darnell, J.E. Nat. Genet. (2006) [Pubmed]
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