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Nyman, U. et al.

Recombinant 70-kD protein used for determination of autoantigenic epitopes recognized by anti-RNP sera.

A panel of high- and low-titre anti-RNP-positive patient sera was tested for reactivity with human snRNP proteins. The U1 snRNP-specific 70-kD peptide was found to be the most prominent RNP antigen recognized by high-titre anti-RNP sera, mainly found in patients with mixed connective tissue disease (MCTD). The reactivity with the 70-kD protein was further analysed with recombinant fusion proteins containing different segments of the protein. One major and two minor antigenic regions were found. Most patient sera, both with high- and low-titre anti-RNP antibodies, only recognized the major region. The most aminoterminal region, showing partial sequence homology with a mouse retroviral p30 gag protein, contained an epitope that was recognized by one serum only.[1]

References

Recombinant 70-kD protein used for determination of autoantigenic epitopes recognized by anti-RNP sera. Nyman, U., Lundberg, I., Hedfors, E., Pettersson, I. Clin. Exp. Immunol. (1990) [Pubmed]

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