Definitive radiotherapy for nasopharyngeal carcinoma.
PURPOSE: We sought to report the outcomes after definitive radiotherapy (RT) for nasopharyngeal carcinoma. METHODS: Between March 1983 and November 2003, 82 patients were treated with curative intent and followed from 0.2 to 22 years (median, 5 years). Follow-up on living patients ranged from 2.8 to 22 years (median, 10.8 years). Thirty-two patients (39%) were treated once daily, 45 patients (55%) were treated with hyperfractionation, and 5 patients (6%) were treated with the concomitant boost technique. Eight patients (10%) received intensity-modulated radiotherapy. Thirty-one patients (38%) received induction (17 patients) or concomitant (14 patients) chemotherapy. Fourteen patients (17%) underwent a planned neck dissection. RESULTS: The 5-year outcomes after treatment were: local control, 78%; regional control, 90%; local-regional control, 76%; distant metastasis-free survival, 80%; cause-specific survival, 66%; and survival, 57%. The impact of T-stage, N-stage, overall stage, World Health Organization class, fractionation schedule, and adjuvant chemotherapy were evaluated in a multivariate analysis of various outcomes. Only N-stage and World Health Organization class impacted regional control. CONCLUSIONS: The likelihood of cure after RT is relatively high. Although the likelihood of cure diminished with increasing stage, none of the parameters evaluated significantly influenced outcomes aside from N-stage and WHO class.[1]References
- Definitive radiotherapy for nasopharyngeal carcinoma. Mendenhall, W.M., Morris, C.G., Hinerman, R.W., Malyapa, R.S., Amdur, R.J. Am. J. Clin. Oncol. (2006) [Pubmed]
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