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Ojo-Amaize, E.A. et al.

Emmanuel A. Ojo-Amaize, Emeka J. Nchekwube, Howard B. Cottam, Olusola A. Oyemade, Akinbo A. Adesomoju, Joseph I. Okogun,

Plasmodium berghei: antiparasitic effects of orally administered hypoestoxide in mice.

Hypoestoxide (HE) is a diterpene isolated from Hypoestes rosea (Acanthaceae), a plant indigenous to Nigeria. Previous studies demonstrated that HE exhibited potent anti-inflammatory and anti-cancer activities in well established animal models but weak in vitro activities in both the anti-inflammation and anti-cancer in vitro screening systems. We now report a similar observation in the in vitro and in vivo screening systems for antimalarial activity. The results indicate that while HE exhibits a relatively weak in vitro activity (IC(50) = 10 microM versus 0.11 microM for chloroquine) against different strains of cultured P. falciparum parasites, the dose of HE required to reduce parasitemia by 90% in Plasmodium berghei-infected mice, is much lower than standard antimalaria drugs (SD(90) = 250 microg/kg versus 5mg/kg for chloroquine). Furthermore, lower doses of HE were much more effective than higher doses in inhibiting parasite development. The implications of these findings are discussed.[1]

References

Plasmodium berghei: antiparasitic effects of orally administered hypoestoxide in mice. Ojo-Amaize, E.A., Nchekwube, E.J., Cottam, H.B., Oyemade, O.A., Adesomoju, A.A., Okogun, J.I. Exp. Parasitol. (2007) [Pubmed]

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