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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
 
 

Distribution of insulin-like growth factors in condylar hyperplasia.

Condylar hyperplasia (CH) is a local overgrowth of the condylar process of the temporomandibular joint (TMJ) of unknown etiology. Probably, growth factors like the insulin-like growth factors (IGFs) are involved in its pathogenesis. Specimens from 12 patients were investigated histologically and immunohistochemically to obtain the distribution of the IGFs-I and -II and the IGF1 receptor. The results revealed juvenile and adult subtypes. While generally IGF-II could only be detected weakly, in the juvenile cases strong immunostaining for IGF-I in cartilage and bone supposes an influence on pathological growth processes.[1]

References

  1. Distribution of insulin-like growth factors in condylar hyperplasia. Götz, W., Lehmann, T.S., Appel, T.R., Rath-Deschner, B., Dettmeyer, R., Luder, H.U., Reich, R.H., Jäger, A. Ann. Anat. (2007) [Pubmed]
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