Proteomics in neuropathic pain research

Anesthesiology. 2008 Feb;108(2):314-23. doi: 10.1097/01.anes.0000299838.13368.6e.

Abstract

Neuropathic pain is often caused by nerve injury or dysfunction in the peripheral and central nervous system and is frequently associated with allodynia and hyperalgesia. The underlying molecular mechanisms of neuropathic pain are largely unknown, and therefore, pharmacologic treatment is insufficient in many cases. To elucidate translational and posttranslational modifications in the nervous system that arise after nerve injury, a number of proteomic studies have been performed using different animal neuropathy models. The results of these proteomic approaches are summarized in this review to provide a better overview of proteins that are involved into the pathogenesis of nerve injury and neuropathic pain. This might allow a better understanding of the pathophysiologic signaling pathways in this impairment, facilitate the discovery of specific biomarkers, and thus promote the development of novel pain therapies.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Disease Models, Animal
  • Electrophoresis, Gel, Two-Dimensional
  • Gene Expression Regulation
  • Models, Biological
  • Pain / genetics*
  • Polyneuropathies / genetics*
  • Proteins / genetics
  • Proteins / isolation & purification
  • Proteomics*
  • Spinal Cord Injuries / genetics

Substances

  • Proteins