- Peripheral virus-specific T-cell interleukin-10 responses develop early in acute hepatitis C infection and become dominant in chronic hepatitis. Kaplan, D.E., Ikeda, F., Li, Y., Nakamoto, N., Ganesan, S., Valiga, M.E., Nunes, F.A., Rajender Reddy, K., Chang, K.M. J. Hepatol. (2008)