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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
 
 
 
 

Periodic remission in Cushing's disease with paradoxical dexamethasone response: an expression of periodic hormonogenesis.

A patient with Cushing's disease due to a chromophobe adenoma was studied for 243 days before pituitary surgery and evidence for periodicity in cortisol steroid production was found with cycles occurring every 85.8 days (peak-to-peak length), associated with laboratory remissions and paradoxical response to dexamethasone. The autonomy of ACTH secretion was suggested by the nonresponsiveness to repeated lysine-vasopressin stimulation tests and lack of increase in urinary 170HCS following metyrapone. A distinct response of the hyperplastic glands (as demonstrated by percutaneous adrenal venography) was obtained on several B1-24 corticotropin stimulation. The patient's hypercortisolism disappeared following removal of the chromophobe adenoma through transphenoidal hypophysectomy.[1]

References

  1. Periodic remission in Cushing's disease with paradoxical dexamethasone response: an expression of periodic hormonogenesis. Liberman, B., Wajchenberg, B.L., Tambascia, M.A., Mesquita, C.H. J. Clin. Endocrinol. Metab. (1976) [Pubmed]
 
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