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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
 
 
 
 

A genetic study of platelet adenylate cyclase activity: evidence for a single major locus effect in fluoride-stimulated activity.

The activity of membrane-bound platelet adenylate cyclase, when stimulated in vitro by several compounds (including fluoride), is significantly reduced in alcoholics compared with control subjects. We have begun a study of the genetics of this enzyme activity. Complex segregation analysis of basal (unstimulated) platelet adenylate cyclase activity in families reveals a mode of inheritance that cannot be accounted for by a simple mixed model of transmission. By contrast, adenylate cyclase activity stimulated by fluoride ion reveals a single major locus effect with a modest multifactorial background. These results suggest that a single factor in the second-messenger pathway may (a) account for the majority of individual differences in stimulation of adenylate cyclase of fluoride and (b) help explain the reduced activities previously observed in alcoholics.[1]

References

  1. A genetic study of platelet adenylate cyclase activity: evidence for a single major locus effect in fluoride-stimulated activity. Devor, E.J., Cloninger, C.R., Hoffman, P.L., Tabakoff, B. Am. J. Hum. Genet. (1991) [Pubmed]
 
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