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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Marchetti, G. et al.

Giulia Marchetti, Giusi M. Bellistrì, Elisa Borghi, Camilla Tincati, Stefania Ferramosca, Maria La Francesca, Giulia Morace, Andrea Gori, Antonella D'Arminio Monforte,

Microbial translocation is associated with sustained failure in CD4+ T-cell reconstitution in HIV-infected patients on long-term highly active antiretroviral therapy.

Patients with inefficient CD4+ T-cell recovery on virogically suppressive highly active antiretroviral therapy constitute a major clinical hurdle given the threat of HIV/AIDS disease progression. We show heightened circulating lipopolysaccharide associated with plasma enterobacterial DNA and highly activated Ki67+CD4+CD8+ in 24 immunologic-nonresponders (CD4+ T-cell < or = 200; HIV-RNA < or = 50) compared with 11 full responders (CD4+ T-cell > or= 400; HIV-RNA < or = 50). These data provide novel insight into INRs pathogenesis, since they correlate augmented systemic translocation of microbial bioproducts with T-cell hyperactivation.[1]

References

Microbial translocation is associated with sustained failure in CD4+ T-cell reconstitution in HIV-infected patients on long-term highly active antiretroviral therapy. Marchetti, G., Bellistrì, G.M., Borghi, E., Tincati, C., Ferramosca, S., La Francesca, M., Morace, G., Gori, A., Monforte, A.D. AIDS (2008) [Pubmed]

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