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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
 
 
 

Interferon gamma is involved in the recovery of athymic nude mice from recombinant vaccinia virus/ interleukin 2 infection.

Athymic nude mice recover from an infection with recombinant vaccinia virus (VV) encoding murine interleukin 2 ( IL-2), but treatment with a mAb to IL-2 accentuated infection. Administration of a mAb against interferon gamma ( IFN-gamma) to mice infected with the IL-2-encoding virus completely prevented the IL-2-induced mechanisms of recovery. Both asialo-GM1+ (NK) and asialo-GM1- (non-NK) cells were participants in the IFN-gamma- mediated recovery of nude mice from infection with the IL-2-encoding VV recombinant. Depletion of asialo-GM1+ cells exacerbated infection, though not as much as anti- IFN-gamma mAb. In vitro, both asialo-GM1+ and asialo-GM1- nude mouse splenocytes produced IFN-gamma in response to IL-2.[1]

References

  1. Interferon gamma is involved in the recovery of athymic nude mice from recombinant vaccinia virus/interleukin 2 infection. Karupiah, G., Blanden, R.V., Ramshaw, I.A. J. Exp. Med. (1990)
 
 
 
 
 
 
 
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