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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
 
 
 
 

Cooperative binding of steroid hormone receptors contributes to transcriptional synergism at target enhancer elements.

We demonstrated previously that two molecules of steroid hormone receptor bound efficiently to a single hormone response element (GRE/PRE) of the tyrosine aminotransferase gene (Tsai et al., 1988). Here, we show that two tandemly linked GRE/PREs conferred progesterone inducibility synergistically to a heterologous TK-CAT fusion gene. Binding studies demonstrated that occupation of one GRE/PRE site by a progesterone receptor dimer increased the binding affinity of receptors for the second GRE/PRE site 100-fold. Thus, the observed synergistic induction of TK-CAT may result from cooperative binding of receptor dimers to the two GRE/PRE sites.[1]

References

  1. Cooperative binding of steroid hormone receptors contributes to transcriptional synergism at target enhancer elements. Tsai, S.Y., Tsai, M.J., O'Malley, B.W. Cell (1989) [Pubmed]
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