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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
 
 

Acute alkalosis, but not acute hypocalcemia, increases panic behavior in an animal model.

Non-pretrained, randomized adult rats were tested in a panic-inducing model of passive avoidance. Intravenous treatment with alkalinizing agents (sodium lactate 0.5 M, 0.5 ml/100 g b.wt., or NaHCO3, 0.5 mEq/100 g b.wt.), but not with a hypocalcemic dose of EDTA (75 mg/kg) 3 min before testing, significantly increased panic behavior. These data may support the hypothesis that panic attacks are due to alkalosis and not to lactate-induced hypocalcemia.[1]

References

  1. Acute alkalosis, but not acute hypocalcemia, increases panic behavior in an animal model. Di Lorenzo, R., Bernardi, M., Genedani, S., Zirilli, E., Grossi, G., Guaraldi, G.P., Bertolini, A. Physiol. Behav. (1987) [Pubmed]
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