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Kainic acid-induced changes of extracellular amino acid levels, evoked potentials and EEG activity in the rabbit olfactory bulb.
The effect of kainic acid (KA) on the extracellular content of amino acids in the rabbit olfactory bulb was investigated, both in vivo with the brain dialysis technique and in vitro with a superfused tissue slice preparation. Olfactory bulb EEG activity and lateral olfactory tract (LOT)-evoked field potentials were monitored simultaneously during dialysis experiments. KA induced a rapid (within 5 min) increase of extracellular aspartate, glutamate, GABA, phosphoethanolamine and taurine in vivo. LOT-evoked potentials were altered concomitantly in a concentration- and time-dependent manner. The antidromic invasion of mitral/tufted cells was depressed and the synaptic activation of granule cells was abolished in the presence of KA. Olfactory bulb EEG activity was also affected. Oscillatory bursts in olfactory bulb EEG were abolished by 10 mM in most experiments, whereas sustained oscillations were induced by 1 mM KA. The effects of KA may partly be due to a blockade of amino acid reuptake since dihydrokainate ( DKA) perfusion was found to increase extracellular aspartate and glutamate. However, DKA had no significant effect on EEG or evoked potentials. In vitro, aspartate and glutamate were selectively increased during KA perfusion.[1]References
- Kainic acid-induced changes of extracellular amino acid levels, evoked potentials and EEG activity in the rabbit olfactory bulb. Jacobson, I., Hamberger, A. Brain Res. (1985)
